Flow Chemistry Projects at University of Graz
For the past decade the focus of research in the Kappe laboratories has been directed towards flow chemistry/microreaction technology, encompassing a wide variety of synthetic transformations and experimental techniques. Funding for these initiatives has been obtained from the Austrian Science Fund (FWF: „Microwave-accelerated Catalysis in Flowthrough Reactors“, 2004-2007), from the Christian Doppler Research Society (CDG: Christan Doppler Laboratories for Microwave (2006-2013) and Flow Chemistry (2013-2015), and from a variety of other sources.
Apart from fundamental research on flow chemistry, microreactor technology, process intensification and continuous processing covering a wide range of scientific disciplines (see, Research), the Kappe laboratory is actively engaged in collaborations with industrial partners, mainly from the pharmaceutical and equipment/technology sectors. In addition, to develop new chemical transformations of interest to API synthesis in flow mode, one of the main objectives is to transfer batch to intensified and scalable commercial continuous processes.
Collaborations with Pharmaceutical Companies
Over the past decade collaborative flow chemistry projects with various pharmaceutical, biotech and agrochemical companies have been pursued. These have led to joint publications (see Publications), patents and validated flow protocols close to industrial implementation. Some of our collaboration partners are listed below.
Collaborations in Large-Scale Continuous Manufacturing and Plant Design
As one of the key goals of the laboratory is to provide scalable solutions to API synthesis, the participation of custom manufacturing organizations (CMOs) with documented experience in commercial scale continuous flow processing such as Lonza (Visp, Switzerland) and Patheon (formerly DSM, Linz, Austria) is of critical importance. Similarly, Microinnova (near Graz, Austria), a company specializing on process integration and process intensification that provides final turnkey flow chemistry plants to its customers, is a valuable partner.