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Recent Hot Papers from the Kappe Lab

Web of Science “Highly Cited Paper"
Continuous-Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
B. Gutmann, D. Cantillo, C. O. Kappe, Angew. Chem. Int. Ed. 2015 , 54, 6688-6729.
DOI: 10.1002/anie.201409318

Integration of Bromine and Cyanogen Bromide Generators for the Telescoped Continuous Synthesis of Cyclic Guanidines
G. Glotz, R. Lebl, D. Dallinger, C. O. Kappe, Angew. Chem. Int. Ed. 2017, 56, 13786-13789.
DOI: 10.1002/anie.201708533

Utilization of Fluoroform for Difluoromethylation in Continuous Flow: A Concise Synthesis of α-Difluoromethyl-Amino Acids
M. Köckinger, T. Ciaglia, M. Bersier, P. Hanselmann, B. Gutmann, C. O. Kappe, Green. Chem. 2018 , 12, 108-112.
DOI: 10.1039/c7gc02913f