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Recent Hot Papers from the Kappe Lab

Photoredox Csp3-Csp2 Reductive Cross-Couplings of Cereblon Ligands for PROTAC Linker Exploration in Batch and Flow
A. Steiner, J. Krieger, R. Jones, D. Boese, Y. Wang, H.-M. Eggenweiler, J. D. Williams, C. O. Kappe, ChemCatChem 2022, 14, e202201184.
DOI: 10.1002/cctc.202201184

Autonomous Multi-Step and Multi-Objective Optimization Facilitated by Real-Time Process Analytics
P. Sagmeister, F. F. Ort, C. E. Jusner, D. Hebrault, T. Tampone, F. G. Buono, J. D. Williams, C. O. Kappe, Adv. Sci. 2022, 12, 2105547.
DOI: 10.1002/advs.202105547

Sustainable Synthesis of Noroxymorphone via a Key Electrochemical N-Demethylation Step
F. Sommer, R. Gerber Aeschbacher, U. Thurnheer, C. O. Kappe, D. Cantillo, ACS Sustain. Chem. Eng. 2022, 10, 8988–8996.
DOI: 10.1021/acssuschemeng.2c02824