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Recent Hot Papers from the Kappe Lab

Laboratory of the Future: A Modular Flow Platform with Multiple Integrated PAT Tools for Multistep Reactions
P. Sagmeister, J. D. Williams, C. A. Hone, C. O. Kappe, React. Chem. Eng. 2019, 4, 1571-1578.
DOI: 10.1039/C9RE00087A

Finding the Perfect Match: A Combined Computational and Experimental Study Towards Efficient and Scalable Photosensitized [2+2] Cycloadditions in Flow
J. D. Williams, M. Nakano, G. Romaric, J. A. Rincon, O. de Frutos, C. Mateos, J. C. M. Monbaliu, C. O. Kappe, Org. Process Res. Dev. 2019, 23, 78-87.
DOI: 10.1002/anie.201708533

Multigram-Scale Flow Synthesis of the Chiral Key Intermediate of (–)-Paroxetine Enabled by Solvent-Free Heterogeneous Organocatalysis
S. B. Ötvös, M. A. Pericas, C. O. Kappe, Chem. Sci. 2019, 10, in press.
DOI: 10.1039/C9SC04752B