Flow Chemistry – Original Papers

A complete list of publications of C. O. Kappe can be found at his personal website


89. Generation of Anhydrous Diazomethane on Lab Scale using Membrane Separation Technology
D. Dallinger, C. O. Kappe, Nature Prot. 2017, 12, in press. DOI: 10.1039/c7ra01087g.
88. Synthesis of Mepivacaine and its Analogues by a Continuous Flow Tandem Hydrogenation−Reductive Amination Strategy
N.S. Suveges, R. O. M. A. de Souza, B. Gutmann, C. O. Kappe, Eur. J. Org. Chem. 2017, 24, in press. DOI: 10.1002/ejoc.201700824.
87. An Integrated Continuous Flow Synthesis of a Key Oxazolidine Intermediate to Noroxymorphone from Naturally Occurring Opioids
A. Mata, D. Cantillo, C. O. Kappe, Eur. J. Org. Chem. 2017, 24, in press. DOI: 10.1002/ejoc.201700811.
86. Continuous Flow Synthesis of Carbonylated Heterocycles via Pd-Catalyzed Oxidative Carbonylation Using CO and O2 at Elevated Temperature and Pressure
Y. Chen, C. A. Hone, B. Gutmann, C. O. Kappe, Org. Process Res. Dev. 2017, 21, in press. DOI: 10.1021/acs.oprd.7b00217.
85. Development of a Continuous-Flow Sonogashira Cross-Coupling Protocol using Propyne Gas under Process Intensified Conditions
D. Znidar, C. Hone, P. Inglesby, A. Boyd, C. O. Kappe, Org. Process Res. Dev. 2017, 21, 878-884. DOI: 10.1021/acs.oprd.7b00160.
84. Development of a Continuous-Flow Process for a Pd-Catalyzed Olefin Cleavage using Oxygen within the Explosive Regime
C. Hone, A. O’Kearney-McMullan, R. Munday, C. O. Kappe, ChemCatChem 2017, 9, in press. DOI: 10.1002/cctc.201700671.
83. Continuous Flow Difluoromethylation with Chlorodifluoromethane under Biphasic Conditions
B. Gutmann, P. Hanselmann, M. Bersier, D. Roberge, C. O. Kappe, J. Flow. Chem. 2017, 7, 46-51. DOI: 10.1556/JFC-D-17-00005.
82. Hydrogen Sulfide Chemistry in Continuous Flow: Efficient Synthesis of 2-Oxopropanethioamide
D. Cantillo, P. A. Inglesby, A. Boyd, C. O. Kappe, J. Flow. Chem. 2017, 7, 29-32. DOI: 10.1556/1846.2017.00006.
81. Reaction Calorimetry in Microreactor Environments – Measuring Heat of Reaction by Isothermal Heat Flux Calorimetry
G. Glotz, D. Knoechel, P. Podmore, H. Gruber-Woelfler, C. O. Kappe, Org. Process Res. Dev. 2017, 21, 763-770. DOI: 10.1021/acs.oprd.7b00092.
80. Continuous Flow Synthesis of Indoles by Pd-catalyzed Deoxygenation of 2-Nitrostilbenes with Carbon Monoxide
G. Glotz, B. Gutmann, P. Hanselmann, A. Kulesza, D. Roberge, C. O. Kappe, RSC Adv. 2017, 7, 10469-10478. DOI: 10.1039/c7ra01087g.
79. Continuous Flow Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization Sequence
D. Cantillo, B. Wolf, R. Goetz, C. O. Kappe, Org. Process Res. Dev. 2017, 21, 125-132. DOI: 10.1021/acs.oprd.6b00409.
78. Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode
B. Gutmann, D. Cantillo, U. Weigl, D. P. Cox, C. O. Kappe, Eur. J. Org. Chem. 2017, 914-927. DOI: 10.1002/ejoc.201601453.
77. Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals – A Fast and Scalable Protocol for Trifluoromethylation
J. L. Monteiro, P. F. Carneiro, P. Elsner, D. Roberge, P. G. M. Wuts, K. Kurjan, B. Gutmann, C. O. Kappe, Chem. Eur. J. 2017, 23, 176-186. DOI: 10.1002/chem.201604579 (selected as ”Hot Paper” by the Editors).
76. Design and Performance Validation of a Conductively Heated Sealed-Vessel Reactor for Organic Synthesis
D. Obermayer, D. Znidar, G. Glotz, A. Stadler, D. Dallinger, C. O. Kappe, J. Org. Chem. 2016, 81, 11788-11801. DOI: 10.1021/acs.joc.6b02242.
75. Continuous-Flow Electrophilic Amination of Arenes and Schmidt Reaction of Carboxylic Acids Utilizing the Superacidic Trimethylsilyl Azide/Triflic Acid Reagent System
Y. Chen, B. Gutmann, C. O. Kappe, J. Org. Chem. 2016, 81, 9372-9380. DOI: 10.1021/acs.joc.6b02085.
74. A Laboratory-Scale Continuous Flow Chlorine Generator for Organic Synthesis
F. J. Strauss, D. Cantillo, J. Guerra, C. O. Kappe, React. Chem. Eng. 2016, 1, 472-476. DOI; 10.1039/c6re00135a. (highlighted by Chemistry World)
73. One-Pot Synthesis of alpha-Haloketones Employing a Membrane-Based Semi-Batch Diazomethane Generator
S. Garbarino, J. Guerra, P. Poechlauer, B. Gutmann, C. O. Kappe, J. Flow Chem. 2016, 6, 211-217. DOI: 10.1556/1846.2015.00046.
72. Towards the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N-Demethylation Strategies
B. Gutmann, P. Elsner, D. P. Cox, U. Weigl, D. M. Roberge, C. O. Kappe, ACS Sust. Chem. Eng. 2016, 4, 6048-6061. DOI: 10.1021/acssuschemeng.6b01371 (invited contribution for special issue: Building on 25 Years of Green Chemistry and Engineering for a Sustainable Future)
71. A Laboratory Scale Reactor for the Generation of Anhydrous Diazomethane
D. Dallinger, V. D. Pinho, B. Gutmann, C. O. Kappe, J. Org. Chem. 2016, 81, 5814-5823. DOI:10.1021/acs.joc.6b01190 (selected as “Featured Article” by the Editors).
70. Batch and Continuous Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines – A Concise Synthesis of Noroxymorphone
B. Gutmann, U. Weigl, D. P. Cox, C. O. Kappe, Chem. Eur. J. 2016, 22, 10393-10398. DOI:10.1002/chem.201601902 (selected as ”Hot Paper” by the Editors).
69. Visible-Light Photoredox Catalysis using a Macromolecular Ruthenium Complex: Reactivity and Recovery by Size-Exclusion Nanofiltration in Continuous Flow
J. Guerra, D. Cantillo, C. O. Kappe, Catal. Sci. Technol. 2016, 6, 4695-4699. DOI: 10.1039/c6cy00070c
68. Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies
B. Pieber, C. O. Kappe, Org. Lett. 2016, 18, 1076−1079. DOI: 10.1021/acs.orglett.6b00194
67. Selective Olefin Reduction in Thebaine Using Hydrazine Hydrate and O2 under Intensified Continuous Flow Conditions
B. Pieber, D. P. Cox, C. O. Kappe, Org. Process Res. Dev. 2016, 20, 376−385. DOI: 10.1021/acs.oprd.5b00370 (invited contribution for special issue: Continuous Processing, Microreactors and Flow Chemistry).
66. Copper/Nafion-Catalyzed Hydroarylation Process Involving Ketenimine Intermediates: A Novel and Synthetic Approach to 4-Sulfonamidoquinoline-2-ones and Derivatives Thereof
B. Reichart, G. Guedes de la Cruz, K. Zangger, C. O. Kappe, T. Glasnov, Adv. Synth. Catal. 2016, 358, 50–55. DOI: 10.1002/adsc.201500942
65. Safe Generation and Use of Bromine Azide under Continuous Flow Conditions ̶ Selective 1,2-Bromoazidation of Olefines
D. Cantillo, B. Gutmann, C. O. Kappe, Org. Biomol. Chem. 2016, 14, 853-857. DOI: 10.1039/c5ob02425k
64. Continuous Synthesis of Hydantoins: Intensifying the Bucherer-Bergs Reaction
J. L. Monteiro, B. Pieber, A. G. Corrêa, C. O. Kappe, Synlett 2016, 27, 83-87. DOI: 10.1055/s-0035-1560317
63. Continuous Flow Preparation of Supported Iron Oxide Nanoparticles on Porous Silicates
A. Yepez, F. L.Y. Lam, A. A. Romero, C. O. Kappe, R. Luque, ChemCatChem 2015, 7, 276–282. DOI: 10.1002/cctc.201402802
62. Singlet Oxygen Oxidation of 5-Hydroxymethylfurfural (5-HMF) in Continuous Flow
T. S. A. Heugebaert, C. V. Stevens, C. O. Kappe, ChemSusChem 2015, 8, 1648-1651. DOI: 10.1002/cssc.201403182
61. Continuous Flow Reduction of Artemisinic Acid Utilizing Multi-Injection Strategies – Closing the Gap Towards a Fully Continuous Synthesis of Antimalarial Drugs
B. Pieber, T. Glasnov, C. O. Kappe, Chem. Eur. J. 2015, 21, 4368-4376. DOI: 10.1002/chem.201406439 (selected as “Hot Paper“ by the Editors, covered by Chemical & Engineering News).
60. Benchmarking Immobilized Di- and Triarylphosphine Palladium Catalysts for Continuous Flow Cross-Coupling Reactions: Efficiency, Durability and Metal Leaching Studies
R. Greco, W. Goessler, D. Cantillo, C. O. Kappe, ACS Catal. 2015, 5, 1303-1312. DOI: 10.1021/cs5020089
59. Nafion-H Catalyzed High-Temperature/High-Pressure Synthesis of a Triarylmethane in Continuous Flow Mode
S. Hayden, T. Glasnov, C. O. Kappe, Chem. Eng. Technol. 2015, 5, 1303-1312. DOI: 10.1002/ceat.201400581
58. A Sequential Ugi Multicomponent/Cu-Catalyzed Azide-Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic Peptoids
C. E. M. Salvador, B. Pieber, P. M. Neu, A. Torvisco, C. K. Z. Andrade, C. O. Kappe, J. Org. Chem. 2015, 80, 4590-4602. DOI: 10.1021/acs.joc.5b00445
57. Light-Induced C−H Arylation of (Hetero)arenes via In Situ Generated Diazo Anhydrides
D. Cantillo, C. Mateos , J. A. Rincon, O. de Frutos, C. O. Kappe, Chem. Eur. J. 2015, 21, 12894-12898. DOI: 10.1002/chem.201502357
56. Development of a Continuous Flow Sulfoxide Imidation Protocol Using Azide Sources under Superacidic Conditions
B. Gutmann, P. Elsner, A. O’Kearney-McMullan, W. Goundry, D. M. Roberge, C. O. Kappe, Org. Process Res. Dev. 2015, 19, 1062-1067. DOI: 10.1021/acs.oprd.5b00217
55. Process Intensified Flow Synthesis of 1H-4-Substituted Imidazoles: Toward the Continuous Production of Daclatasvir
P. F. Carneiro, B. Gutmann, R. O. M. A. de Souza, C. O. Kappe, ACS Sust. Chem. Eng. 2015, 3, 3445−3453. DOI: 10.1021/acssuschemeng.5b01191
54. A Scalable Procedure for Light Induced Benzylic Brominations in Continuous Flow
D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe, J. Org. Chem. 2014, 79, 223-229. DOI: 10.1021/jo402409k
53. Continuous Flow alpha-Trifluoromethylation of Ketones by Metal Free Visible Light Photoredox Catalysis
D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe, Org. Lett. 2014, 17, 5590-5593. DOI: 10.1021/ol403650y (Web of Science Highly Cited Article).
52. Continuous Flow Synthesis of alpha-Haloketones – Essential Building Blocks of Antiretroviral Agents
V. D. Pinho, B. Gutmann, L. S. M. Miranda, R. O. M. A. de Souza, C. O. Kappe, J. Org. Chem. 2014, 79, 1555-1562. DOI: 10.1021/jo402849z (selected as “Featured Article” by the Editors).
51. Flash Carboxylation: Fast Lithiation – Carboxylation Sequence at Room Temperature in Continuous Flow
B. Pieber, T. Glasnov, C. O. Kappe, RSC Adv. 2014, 4, 13430-13433. DOI: 10.1039/c4ra01442a
50. Combined Batch and Continuous Flow Procedure to the Chemo-Enzymatic Synthesis of Biaryl Moiety of Odanacatib
R. de Oliveira Lopes, A. S. de Miranda, B. Reichart, T. Glasnov, C. O. Kappe, R. C. Simon, W. Kroutil, L. S. M. Miranda, I. C. R.Leal, R. O. M. A. de Souza, Mol. Catal. B. 2014, 104, 101-107. DOI: 10.1016/j.molcatb.2014.03.017
49. Chemistry of Pyrrolizidine Alkaloids Revisited – Semi-Synthetic Microwave and Continuous-Flow Approaches towards Crotalaria-Alkaloids
S. T. Martinez, A. C. Pinto, T. Glasnov, C. O. Kappe, Tetrahedron Lett. 2014, 55, 4181-4184. DOI: 10.1016/j.tetlet.2014.05.055
48. A Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol − Safe Generation and Use of an Explosive Intermediate under Continuous Flow Conditions
D. Cantillo, M. Damm, D. Dallinger, M. Bauser, M. Berger, C. O. Kappe, Org. Process Res. Dev. 2014, 18, 1360-1366. DOI: 10.1021/op5001435 (invited contribution for special issue: Continuous Processes 14)
47. Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine-mediated Nitro Reductions in Continuous Flow
M. Mirhosseini Moghaddam, B. Pieber, T. Glasnov, C. O. Kappe, ChemSusChem 2014, 7, 3122-3131. DOI: 10.1002/cssc.201402455
46. Shifting Chemical Equilibria in Flow – Efficient Decarbonylation Chemistry Driven by Annular Flow Regimes
B. Gutmann, P. Elsner, T. Glasnov, D. M. Roberge, C. O. Kappe, Angew. Chem. Int. Ed. 2014, 53, 11557-11561. DOI: 10.1002/anie.201407219
45. Continuous Flow Synthesis of beta-Amino Acids from alpha-Amino Acids via Arndt-Eistert Homologation
V. D. Pinho, B. Gutmann, C. O. Kappe, RSC Adv. 2014, 4, 37419-37422. DOI: 10.1039/c4ra08113g
44. A Continuous Flow Protocol for Light-Induced Benzylic Fluorination
D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos, C. O. Kappe, J. Org. Chem. 2014, 79, 8486-8490. DOI: 10.1021/jo5016757
43. Continuous Flow Synthesis of n-Alkyl Chlorides in a High-Temperature Microreactor Environment
B. Reichart, G. Tekautz, C. O. Kappe, Org. Process Res. Dev. 2013, 17, 152-156. DOI: 10.1021/op300273u
42. Direct Aerobic Oxidation of 2-Benzylpyridines in a Gas-Liquid Continuous-Flow Regime Using Propylene Carbonate as Solvent
B. Pieber, C. O. Kappe, Green Chem. 2013, 15, 320-324. DOI: 10.1039/c2gc36896j
41. On the Fischer Indole Synthesis of 7-Ethyltryptophol- Mechanistic and Process Intensification Studies under Continuous Flow Conditions
B. Gutmann, M. Gottsponer, P. Elsner, D. Cantillo, D. M. Roberge, C. O. Kappe, Org. Process Res. Dev. 2013, 17, 294-302. DOI: 10.1021/op300363s
40. Nanocatalysis in Continuous Flow: Supported Iron Oxide Nanoparticles for the Heterogeneous Aerobic Oxidation of Benzyl Alcohol
D. Obermayer, A. M. Balu, A. A. Romero, W. Goessler, R. Luque, C. O. Kappe, Green Chem. 2013, 15, 1530-1537. DOI: 10.1039/c3gc40307f
39. Continuous Flow Synthesis of Adipic Acid from Cyclohexene Using Hydrogen Peroxide in High-Temperature Explosive Regimes
M. Damm, B. Gutmann, C. O. Kappe, ChemSusChem 2013, 6, 978-982. DOI: 10.1002/cssc.201300197
38. Hydrazine-Mediated Reduction of Nitro and Azide Functionalities Catalyzed by Highly Active and Reusable Magnetic Iron Oxide Nanocrystals
D. Cantillo, M. Mirhosseini Moghaddam, C. O. Kappe, J. Org. Chem. 2013, 78, 4530-4542. DOI: 10.1021/jo400556g
37. Continuous-flow Synthesis of CdSe Quantum Dots: A Size Tunable and Scalable Approach
M. M. Moghaddam, M. Baghbanzadeh, A. Sadeghpour, O. Glatter, C. O. Kappe, Chem. Eur. J. 2013, 19, 11629-11636. DOI: 10.1002/chem.201301117
36. Versatile Low-loaded Mechanochemically Synthesized Supported Iron Oxide Nanoparticles for Continuous Flow Alkylations
A. M. Balu, A. Pineda, D. Obermayer, A. A. Romero, C. O. Kappe, R. Luque, RSC Adv. 2013, 3, 16292-16295. DOI: 10.1039/c3ra43160f
35. In Situ Generation of Diimide from Hydrazine and Oxygen – Transfer Hydrogenation of Olefins in Continuous Flow
B. Pieber, S. T. Martinez, D. Cantillo, C. O. Kappe, Angew. Chem. Int. Ed. 2013, 52, 10241-10244. DOI: 10.1002/anie.201303528
34. Continuous-flow Production of Photocatalytically Active Titanium Dioxide Nanocrystals and its Application to the Photocatalytic Addition of N,N-Dimethylaniline to N-Methylmaleimide
M. Baghbanzadeh, T. N. Glasnov, C. O. Kappe, J. Flow Chem. 2013, 3, 109-113. DOI: 10.1556/JFC-D-13-00018
33. A Three Step Continuous Flow Synthesis of the Biaryl Unit of the HIV Protease Inhibitor Atazanavir
L. Dalla-Vechia, B. Reichart, T. N. Glasnov, L. S. M. Miranda, C. O. Kappe, R. O. M. A. de Souza, Org. Biomol. Chem. 2013, 11, 6806-6813. DOI: 10.1039/c3ob41464g
32. Phase-Transfer Catalysis – Mixing Effects in Continuous-Flow Liquid/Liquid O- and S-Alkylation Processes
B. Reichart, C. O. Kappe, T. N. Glasnov, Synlett 2013, 24, 2393-2396. DOI: 10.1055/s-0033-1339839
31. Direct Preparation of Nitriles from Carboxylic Acids in Continuous Flow
D. Cantillo, C. O. Kappe, J. Org. Chem. 2013, 78, 10567-10571. DOI: 10.1021/jo401945r
30. Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF 2400 Tube-in-Tube Reactor
F. Mastronardi, B. Gutmann, C. O. Kappe, Org. Lett. 2013, 16, 5590-5593. DOI: 10.1021/ol4027914 (covered by „In the Pipeline“ Blog)
29. Homogeneous Liquid-Phase Oxidation of Ethylbenzene to Acetophenone in Continuous Flow Mode
B. Gutmann, P. Elsner, D. Roberge, C. O. Kappe, ACS Catal. 2013, 3, 2669-2676. DOI: 10.1021/cs400571y
28. High-Temperature Continuous Flow Synthesis of 1,3,4-Oxadiazoles via N-Acylation of 5-Substituted Tetrazoles
B. Reichart, C. O. Kappe, Tetrahedron Lett. 2012, 53, 952-955. DOI: 10.1016/j.tetlet.2011.12.043
27. Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe, J. Flow Chem. 2012, 2,8-19. DOI: 10.1556/jfchem.2012.00021
26. Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environment
D. Cantillo, H. Sheibani, C. O. Kappe, J. Org. Chem. 2012, 77, 2463-2473. DOI: 10.1021/jo3001645
25. Copper-Catalyzed C-O Bond Formation by Direct a-C-H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous Flow Formats
G. S. Kumar, B. Pieber, K. R. Reddy, C. O. Kappe, Chem. Eur. J. 2012, 18, 6124-6128. DOI: 10.1002/chem.201200815
24. Microwave-assisted Continuous Flow Synthesis on Industrial Scale
R. Morschhäuser, M. Krull, C. Kayser, C. Boberski, R. Bierbaum, P. A. Püschner, T. N. Glasnov, C. O. Kappe, Green Process. Synthesis 2012, 1, 281-290. DOI 10.1515/gps-2012-0032
23. In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes in Continuous Flow.
D. Cantillo, M. Baghbanzadeh, C. O. Kappe, Angew. Chem. Int. Ed. 2012, 51, 10190-10193. DOI: 10.1002/anie.201205792 (Web of Science Highly Cited Article).
22. Methylation Using Dimethylcarbonate Catalysed by Ionic Liquids Under Continuous Flow Conditions
T. N. Glasnov, J. D. Holbrey, C. O. Kappe, K. R. Seddon, T. Yan, Green Chem. 2012, 14, 3071-3076. DOI: 10.1039/c2gc36226k
21. A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones
M. Viviano, T. N. Glasnov, B. Reichart, G. Tekautz, C. O. Kappe, Org. Process Res. Dev. 2011, 15, 858-870. DOI: 10.1021/op2001047
20. Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides
D. Obermayer, T. N. Glasnov, C. O. Kappe, J. Org. Chem. 2011, 76, 6657-6669. DOI: 10.1021/jo2009824
19. Microwave-assisted Grafting to MCM-41 Silica and its Application as Catalyst in Flow Chemistry
M. Oliverio, A. Procopio, T. N. Glasnov, W. Goessler, C. O. Kappe, Aust. J. Chem. 2011, 64, 1522-1529. DOI: 10.1071/CH11125
18. A Two-Step Continuous Flow Synthesis of N-(2-Aminoethyl)acylamides via Ring- Opening/Hydrogenation of Oxazolines
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe, Chem. Eur. J. 2011, 17, 13146–13150. DOI: 10.1002/chem.201102772 (featured in Synfacts 2012, 8, 221).
17. Unusual Behavior in the Reactivity of 5-Substituted-1H-tetrazoles in a Resistance-Heated  Microreactor
B. Gutmann, T. N. Glasnov, T. Razzaq, W. Goessler, D. M. Roberge, C. O. Kappe, Beilstein. J. Org. Chem. 2011, 7, 503-517. DOI: 10.3762/bjoc.7.59
16. Pentafluorophenyl-bis(diethylamino)phosphane – A Push-Pull Phosphane Available for Coordination
A. Orthaber, M. Fuchs, F. Belaj, G. N. Rechberger, C. O. Kappe, R. Pietschnig, Eur. J. Inorg. Chem. 2011, 2588-2596. DOI: 10.1002/ejic.201100138
15. Continuous Flow Ozonolysis in a  Laboratory Scale Reactor
M. Irfan, T. N. Glasnov, C. O. Kappe, Org. Lett. 2011, 14, 984-987. DOI: 10.1021/ol102984h
14. Toward a Continuous Flow Synthesis of Boscalid
T. N. Glasnov, C. O. Kappe, Adv. Synth. Catal. 2010, 352, 3089-3097. DOI: 10.1002/adsc.201000646
13. Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles and Hydrazoic Acid Using a Safe and Scalable High-Temperature Microreactor Approach
B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe, Angew. Chem. Int. Ed. 2010, 49, 7101-7105. DOI: 10.1002/anie.201003733
12. Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction
J. B. Bariwal, D. S. Ermolat’ev, T. N. Glasnov, K. Van Hecke, V. P. Mehta, L. Van Meervelt, C. O. Kappe, E. Van der Eycken, Org. Lett. 2010, 13, 2774–2777. DOI: 10.1021/ol1008729
11. Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes
M. Damm, T. N. Glasnov, C. O. Kappe, Org. Process Res. Dev. 2010, 14, 215-224. DOI: 10.1021/op900297e
10. Mechanistic Insights Into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions Using Continuous Flow Conditions
M. Fuchs, W. Goessler, C. Pilger, C. O. Kappe, Adv. Synth. Catal. 2010, 352, 323-328. DOI: 10.1002/adsc.200900726
9. Accessing Novel Process Windows in a High-Temperature/Pressure Capillary Flow Reactor
T. Razzaq, T. N. Glasnov, C. O. Kappe, Chem. Eng. Technol. 2009, 32, 1702-1716. DOI: 10.1002/ceat.200900272
8. Continuous Flow Microreactor Chemistry Under High Temperature/Pressure Conditions
T. Razzaq, T. N. Glasnov, C. O. Kappe, Eur. J. Org. Chem. 2009, 1321-1325. DOI: 10.1002/ejoc.200900077
7. Continuous Flow Hydrogenation of Functionalized Pyridines
M. Irfan, E. Petricci, T. N. Glasnov, M. Taddei, C. O. Kappe, Eur. J. Org. Chem. 2009, 1326-1334. DOI: 10.1002/ejoc.200801131
6. Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki-Heck Reactions. A Comparison of Batch/Microwave and Continuous Flow Processing
T. N. Glasnov, S. Findenig, C. O. Kappe, Chem. Eur. J. 2009, 15, 1001-1015. DOI: 10.1002/chem.200802200
5. Palladium(0) Nanoparticles on Glass-Polymer Composite Materials as Recyclable Catalysts: A Comparison Study on Their Use in Batch and Continuous Flow Processes
K. Mennecke, R. Cecilia, T. N. Glasnov, S. Gruhl, C. Vogt, A. Feldhoff, M. A. L. Vargas, C. O. Kappe, U. Kunz, A. Kirschning, Adv. Synth. Catal. 2008, 350, 717-730. DOI: 10.1002/adsc.200700510
4. Microwave-assisted Dimroth Rearrangement of Thiazines to Dihydropyrimidinethiones: Synthetic and Mechanistic Aspects.
T. N. Glasnov, D. J. Vugts, M. M. Koningstein, B. Desai, W. M. F. Fabian, R. V. A. Orru, C. O. Kappe, QSAR Comb. Sci. 2006, 25, 509-518. DOI: 10.1002/qsar.200540210
3. Microwave-assisted Solution Phase Synthesis of Dihydropyrimidine C5 Amides and Esters
B. Desai, D. Dallinger, C. O. Kappe, Tetrahedron 2006, 62, 4651-4664. DOI: 10.1016/j.tet.2005.12.061
2. Monolithic Polymer/Carrier Materials: Versatile Composites for Fine Chemical Synthesis
U. Kunz, A. Kirschning, H.-L. Wen, W. Solodenko, R. Cecilia, C. O. Kappe, T. Turek, Catal. Today 2005, 105, 318-324. DOI: 10.1016/j.cattod.2005.06.046
1. Heterogeneous Hydrogenation Reactions Using a Continuous Flow High Pressure Device
B. Desai, C. O. Kappe, J. Comb. Chem. 2005, 7, 641-643. DOI: 10.1021/cc050076x