Medicines for All Institute
In August of 2017 The Virginia Commonwealth University (VCU) School of Engineering (Richmond, VA, USA) has been awarded a $25 million grant from the Bill & Melinda Gates Foundation to establish the Medicines for All Institute to fund work on a wide range of essential global health treatments. With this grant, the institute will support access to lifesaving medications for HIV/AIDS, malaria, tuberculosis and other diseases around the world.
The Kappe Laboratory and RCPE has been an academic partner in this endeavor. The 4-year subaward (7/2017-6/2021) has supported Ph.D. students in Graz with research initially aimed at achieving cost effective access to a critical HIV/AIDS drug. Key to the project will be using continuous flow technology, in particular the concept of utilizing chemistry that is too difficult or dangerous to perform in conventional batch-type reactors (forbidden chemistries).
Publication: A High-Yielding Synthesis of EIDD-2801 from Uridine
A. Steiner, D. Znidar, S. B. Ötvös, D. R. Snead, D. Dallinger, C. O. Kappe, Eur. J. Org. Chem. 2020, 26, 6736-6739 DOI: 10.1002/ejoc.202001340.