Flow Chemistry – Original Papers
A complete list of publications of C. O. Kappe can be found at his Web of Science account
| 229. | Can a Simple Surrogate Model System be Used to Develop a Continuous Flow Packed Bed Hydrogenation for a Complex Molecule? S. Martinuzzi, M. Mex, J. Milic, C. A. Hone, C. O. Kappe, Org. Process Res. Dev. 2025, 29, in press. DOI: 10.1021/acs.oprd.4c00180. |
| 228. | Model-based Real-time Optimization in Continuous Pharmaceutical Manufacturing H. Damiri, M. Steinberger, L. Kuchler, A. Azimi, S. Martinuzzi, P. Sagmeister, J. D. Williams, S. Koch, M. Tranninger, J. Rehrl, S. Celikovic, S. Sacher, C. O. Kappe, M. Horn, Comp. Chem. Eng. 2025, 192, 108915. DOI: 10.1016/j.compchemeng.2024.108915. |
| 227 | Sustainability Assessment during Early-Stage Chemical Process Design Comparing Two Different Methods of Synthesizing Noroxymorphone G. Egger, K. Waniek, J.-P. Schöggl, C. O. Kappe, R. J. Baumgartner, ACS Sustain. Chem. Eng. 2025, 13, in press. DOI: 10.1021/acssuschemeng.4c07930. |
| 226. | Scalable Electrocatalyzed Formation of C–O Bonds Using Flow Reactor Technology M. Prieschl, D. Cantillo, C. O. Kappe, G. Laudadio, React. Chem. Eng. 2025, 10, 130-134. DOI: 10.1039/D4RE00438H. |
| 225. | An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization E. Rial-Rodríguez, J. D. Williams, D. Cantillo, T. Fuchß, A. Sommer, H.-M. Eggenweiler, C. O. Kappe, G. Laudadio, Angew. Chem. Int. Ed. 2024, 63, e202412045. DOI: 10.1002/anie.202412045. |
| 224. | Scalable Catalyst Free Electrochemical Chlorination of Aminophenol Derivatives Enabled by a Quasi-divided Cell Approach B. K. Malviya, G. Laudadio, C. O. Kappe, D. Cantillo, Green Chem. 2024, 26, 10479–10485. DOI: 10.1039/D4GC03569K. |
| 223. | General and Versatile Synthesis of Highly Recyclable Chiral Phosphoric Acid Organocatalyst A. Maestro, S. B. Ötvös, G. Auer, C. O. Kappe, Org. Chem. Front. 2024, 11, 5901–5907. DOI: 10.1039/d4qo01442a. |
| 222. | Simultaneous Reaction- and Analytical Model Building Using Dynamic Flow Experiments to Accelerate Process Development P. Sagmeister, L. Melnizky, J. D. Williams, C. O. Kappe, Chem. Sci. 2024, 15, 12523–12533. DOI: 10.1039/D4SC01703J. |
| 221. | Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF4) and Dialkyamines in Continuous Flow Mode D. Polterauer, S. Wagschal, Michael Bersier, C. Bovino, D. M. Roberge, C. A. Hone, C. O. Kappe, Org. Process Res. Dev. 2024, 28, 2919-2927. DOI: 10.1021/acs.oprd.4c00180. |
| 220. | Design of Experiments-Based Optimization of an Electrochemical Decarboxylative Alkylation using a Spinning Cylinder Electrode Reactor N. Petrović, G. Cumming, C. A. Hone, M. J. Nieves-Remacha, P. Garcia-Losada, O. de Frutos, C. O. Kappe, D. Cantillo, Org. Process Res. Dev. 2024, 28, 2928-2934. DOI: 10.1021/acs.oprd.4c00178. |
| 219. | Self-Optimizing Flow Reactions for Sustainability: An Experimental Bayesian Optimization Study F. L. Wagner, P. Sagmeister, T. G. Tampone, V. Manee, D. Yerkozhanov, F. G. Buono, J. D. Williams, C. O. Kappe, ACS Sustain. Chem. Eng. 2024, 12, 10002-10010. DOI: 10.1021/acssuschemeng.4c03253. |
| 218. | Experimental and Computational Investigation of Fluid Flow and Solid Transport in Split-And-Recombine Oscillatory Flow Reactors for Organic Chemistry in Water F. Nanto, S. B. Ötvös, C. O. Kappe, P. Canu, J. Ind. Eng. Chem. 2024, 138, 392-402. DOI: 10.1016/j.jiec.2024.04.016. |
| 217. | Preparation of Sulfonyl Chlorides by Oxidative Chlorination of Thiols and Disulfides using HNO3/HCl/O2 in a Flow Reactor N. Sulzer, D. Polterauer, C. A. Hone, C. O. Kappe, ChemSusChem 2024, 17, e202400292. DOI: 10.1002/cssc.202400292. |
| 216. | A Robust Heterogeneous Chiral Phosphoric Acid Enables Multi Decagram Scale Production of Optically Active N,S-Ketals A. Maestro, B. K Malviya, G. Auer, S. B. Ötvös, C. O. Kappe, Green Chem. 2024, 26, 4593–4599. DOI: 10.1039/D4GC00019F. |
| 215. | Scalable Quasi-divided Cell Operation using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axinitib Intermediate B. K. Malviya, E. Hansen, C. Kong, J. Imbrogno, J. Verghese, S. Guinness, C. Salazar, J.-N. Desrosiers, C. O. Kappe, D. Cantillo, Org. Process Res. Dev. 2024, 28, 790–797. DOI: 10.1021/acs.oprd.3c00508. |
| 214. | Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence D. Polterauer, K. M. P. van Eeten, W. Stam, C. A. Hone, C. O. Kappe, Org. Process Res. Dev. 2024, 28, 1903-1909. DOI: 10.1021/acs.oprd.3c00448. |
| 213. | Aniline Derivatives from Lignin Under Mild Conditions Enabled by Electrochemistry A. A. Castillo-Garcia, C. O. Kappe, D. Cantillo, K. Barta, ChemSusChem 2024, 17, e202301374. DOI: 10.1002/cssc.202301374. |
| 212. | A Slug Flow Platform with Multiple Process Analytics Facilitates Flexible Reaction Optimization F. Wagner, P. Sagmeister, C. E. Jusner, T. G. Tampone, V. Manee, F. G. Buono, J. D. Williams, C. O. Kappe, Adv. Sci. 2024, 14, 2308034. DOI: 10.1002/advs.202308034. |
| 211. | Enantioselective Flow Synthesis of a Tetrahydroquinoline SERM Enabled by Immobilized Chiral Phosphoric Acid Catalysis and Diboronic Acid Mediated Selective Nitro Reduction B. S. Nagy, A. Maestro, M. B. Chaudhari, C. O. Kappe, S. B. Ötvös, Adv. Synth. Catal. 2024, 366, 1024–1030. DOI: 10.1002/adsc.202301387. |
| 210. | A Low-Volume Flow Electrochemical Microreactor for Rapid and Automated Process Optimization E. Rial-Rodríguez, J. F. Wagner, H.-M. Eggenweiler, T. Fuchss, A. Sommer, C. O. Kappe, J. Williams, D. Cantillo, React. Chem. Eng. 2024, 9, 31-36. DOI: 10.1039/D3RE00586K. |
| 209. | Development of an Open-Source Flow-Through Cyclic Voltammetry Cell for Real-Time Inline Reaction Analytics E. Rial-Rodríguez, J. Williams, H.-M. Eggenweiler, T. Fuchss, A. Sommer, C. O. Kappe, D. Cantillo, React. Chem. Eng. 2024, 9, 26-30. DOI: 10.1039/D3RE00535F. |
| 208. | Dynamic Experiments in Flow Accelerate Reaction Network Definition in a Complex Hydrogenation Using Catalytic Static Mixers S. Martinuzzi, M. Tranninger, P. Sagmeister, M. Horn, J. D. Williams, C. O. Kappe, React. Chem. Eng. 2024, 9, 132-138. DOI: 10.1039/D3RE00451A. |
| 207. | Application of an Oscillatory Plug Flow Reactor to Enable Scalable and Fast Reactions in Water Using a Biomass-Based Polymeric Additive S. Hammer, F. Nanto, P. Canu, S. B. Oetvoes, C. O. Kappe, ChemSusChem 2024, 17, e202301149. DOI: 10.1002/cssc.202301149. |
| 206. | Investigations on the Continuous Flow Generation of 2,6-Dichloro-N-fluoropyridinium Tetrafluoroborate using F2 Gas K. Simon, D. Znidar, G. Glotz, D. Dallinger, C. O. Kappe, J. Flow. Chem. 2023, 13, 427-434. DOI: 10.1007/s41981-023-00291-z. |
| 205. | Leveraging Flow Chemistry for the Synthesis of Trisubstituted Isoxazoles M. Prieschl, N. Sulzer, J. Sedelmeier, D. Kaldre, R. Lebl, K. Püntener, S. Hildbrand, J. D. Williams, C. O. Kappe, J. Flow. Chem. 2023, 13, 405-411. DOI: 10.1007/s41981-023-00288-8. |
| 204. | Sulfur Tetrafluoride (SF4) as a Deoxyfluorination Reagent for Organic Synthesis in Continuous Flow Mode D. Polterauer, P. Hanselmann, R. Littich, M. Bersier, D. M. Roberge, S. Wagschal, C. A. Hone, C. O. Kappe, Org. Process Res. Dev. 2023, 27, 2385−2392. DOI: 10.1021/acs.oprd.3c00422. |
| 203. | Electrifying Friedel-Crafts Intramolecular Alkylation Towards 1,1-Disubstituted Tetrahydronaphthalenes E. Lunghi, P. Ronco, F. Della Negra, B. Trucchi, M. Verzini, E. Casali, C. O. Kappe, D. Cantillo, G. Zanonia, J. Org. Chem. 2023, 88, 16783−16789. DOI: 10.1021/acs.joc.3c01281. |
| 202. | A Telescoped Continuous Flow Enantioselective Process for Accessing Intermediates of 1-Aryl-1,3-diols as Chiral Building Blocks A. Maestro, B. S. Nagy, S. Oetvoes, C. O. Kappe, J. Org. Chem. 2023, 88, 15523-15529. DOI: 10.1021/acs.joc.3c02040. |
| 201. | A Multigram Electrochemical Hofmann Rearrangement using a Spinning Three-Dimensional Anode B. K. Malviya, C. Bottecchia, K. Stone, D. Lehnherr, F. Lévesque, C. O. Kappe, D. Cantillo, Org. Process Res. Dev. 2023, 27, 2183-2191. DOI: 10.1021/acs.oprd.3c00332. |
| 200. | Scaling-up Electroorganic Synthesis Using a Spinning Electrode Electrochemical Reactor in Batch and Flow Mode N. Petrović, B. K. Malviya, C. O. Kappe, D. Cantillo, Org. Process Res. Dev. 2023, 27, 2072-2081. DOI: 10.1021/acs.oprd.3c00255. |
| 199. | Metal-Free Electrochemical Reduction of Disulfides in an Undivided Cell under Mass Transfer Control B. K. Malviya, E. C. Hansen, C. J. Kong, J. Imbrogno, J. Verghese, S. M. Guinness, C. A. Salazar, J.-N. Desrosiers, C. O. Kappe, D. Cantillo, Chem. Eur. J. 2023, 62, e202302664. DOI: 10.1002/chem.202302664. |
| 198. | Accelerating Reaction Modeling Using Dynamic Flow Experiments, Part 1: Design Space Exploration P. Sagmeister, C. Schiller, P. Weiss, K. Silber, S. Knoll, C. A. Hone, J. D. Williams C. O. Kappe, React. Chem. Eng. 2023, 8, 2818-2825. DOI: 10.1039/D3RE00243H. |
| 197. | Accelerating Reaction Modeling Using Dynamic Flow Experiments, Part 2: Development of a Digital Twin K. Silber, P. Sagmeister, C. Schiller, J. D. Williams, C. A. Hone, C. O. Kappe, React. Chem. Eng. 2023, 8, 2849-2855. DOI: 10.1039/D3RE00244F. |
| 196. | Electrochemical Nickel-Catalyzed C(sp3)–C(sp3) Cross-Coupling of Alkyl Halides with Alkyl Tosylates M. Y. S. Ibrahim, G. R. Cumming, R. Gonzalez de Vega, P. Garcia-Losada, O. de Frutos, C. O. Kappe, D. Cantillo, J. Amer. Chem. Soc 2023, 145, 17023-17028. DOI: 10.1021/jacs.3c07313. |
| 195. | Continuous Flow Process Development for the Synthesis of an Industrial Raw Material via Solvent‑free Aromatic Claisen Rearrangement N. Petrovic, S B. Ötvös, C. O. Kappe, J. Flow. Chem. 2023, 13, 443-447. DOI: 10.1007/s41981-023-00275-z. |
| 194. | Rediscovering Cyanogen Gas for Organic Synthesis: Formation of 2-Cyanothiazole Derivatives M. Prieschl, J. Sedelmeier, K. Püntener, S. Hildbrand, J. D. Williams, C. O. Kappe, J. Org. Chem. 2023, 88, 9594−9598. DOI: 10.1021/acs.joc.3c01110. |
| 193. | Merger of Visible Light-driven Chiral Organocatalysis and Continuous Flow Chemistry: An Accelerated and Scalable Access into Enantioselective α-Alkylation of Aldehydes M. Molnár, C. O. Kappe, S. B. Ötvös, Adv. Synth. Catal. 2023, 365, 1660-1670. DOI: 10.1002/adsc.202300289. |
| 192. | Continuous-Flow Synthesis of Δ9-Tetrahydrocannabinol and Δ8-Tetrahydrocannabinol from Cannabidiol B. Bassetti, C. A. Hone, C. O. Kappe, J. Org. Chem. 2023, 88, 6227-6231. DOI: 10.1021/acs.joc.3c00300. |
| 191. | Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 1: Azidation and [3+2] Cycloaddition P. Sagmeister, M. Prieschl, D. Kaldre, C. J. Gadiyar, J. Sedelmeier, C. Moessner, J. D. Williams, C. O. Kappe, Org. Process Res. Dev. 2023, 7, 592-600. DOI: 10.1021/acs.oprd.3c00035. |
| 190. | Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 2: Cy-clization, Chlorination and Amination M. Prieschl, P. Sagmeister, D. Kaldre, J. Sedelmeier, C. Moessner, J. D. Williams, C. O. Kappe, Org. Process Res. Dev. 2023, 7, 601-609. DOI: 10.1021/acs.oprd.3c00036. |
| 189. | Harnessing a Continuous Flow Persulfuric Acid Generator for Direct Oxidative Aldehyde Esterifications B. S. Nagy, G. Fu, C. A. Hone, C. O. Kappe, S. B. Oetvoes, ChemSusChem 2023, 16, e202201868. DOI: 10.1002/cssc.202201868. |
| 188. | Asymmetric Synthesis of Trisubstituted Piperidines via Biocatalytic Transamination and Diastereoselective Enamine or Imine Reduction P. Petermeier, C. Kohlfuerst, A. Torvisco, R. C. Fischer, A. Mata, D. Dallinger, C. O. Kappe, J. H. Schrittwieser, W. Kroutil, Adv. Synth. Catal. 2023, 365, 2188-2202. DOI: 10.1002/adsc.202300050. |
| 187. | Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in Continuous Flow Mode K. Simon, D. Znidar, J. Boutet, G. Guillamot, J.-Y. Lenoir, D. Dallinger, C. O. Kappe, Org. Process Res. Dev. 2023, 7, 323-330. DOI: 10.1021/acs.oprd.2c00348. |
| 186. | Thermal Characterization of Highly Exothermic Flash Chemistry in a Continuous Flow Calorimeter G. Fu, J. Jiang, C. A Hone, C. O. Kappe, React. Chem. Eng. 2023, 8, 577-591. DOI: 10.1039/D2RE00439A. |
| 185. | Control of a Complex Multistep Process for the Production of Mesalazine I. Castillo, J. Rehrl, P. Sagmeister, R. Lebl, J. Kruisz, S. Celikovica, M. Sipek, D. Kirschneck, M. Horn, S. Sacher, D. Cantillo, J. D. Williams, J. G. Khinast, C. O. Kappe, J. Process Contr. 2023, 152, 59-62. DOI: 10.1016/j.jprocont.2022.12.009. |
| 184. | Photoredox Csp3-Csp2 Reductive Cross-Couplings of Cereblon Ligands for PROTAC Linker Exploration in Batch and Flow A. Steiner, J. Krieger, R. Jones, D. Boese, Y. Wang, H.-M. Eggenweiler, J. D. Williams, C. O. Kappe, ChemCatChem 2022, 14, e202201184. DOI: 10.1002/cctc.202201184. |
| 183. | A Continuous Flow Investigation of Sulfonyl Chloride Synthesis Using N-Chloroamides: Optimization, Kinetics and Mechanism D. Polterauer, D. M. Roberge, P. Hanselmann, R. Littich, C. A Hone, C. O. Kappe, React. Chem. Eng. 2022, 7, 2582–2592. DOI: 10.1039/D2RE00280A. |
| 182. | Sustainable Synthesis of Noroxymorphone via a Key Electrochemical N-Demethylation Step F. Sommer, R. Gerber Aeschbacher, U. Thurnheer, C. O. Kappe, D. Cantillo, ACS Sustain. Chem. Eng. 2022, 10, 8988–8996. DOI: 10.1021/acssuschemeng.2c02824. |
| 181. | Autonomous Model-Based Experimental Design for Rapid Reaction Development S. Knoll, C. E. Jusner, P. Sagmeister, J. D. Williams, C. A Hone, M. Horn, C. O. Kappe, React. Chem. Eng. 2022, 7, 2375–2384. DOI: 10.1039/D2RE00208F. |
| 180. | Synthesis of Thiomorpholine via a Telescoped Photochemical Thiol-ene/Cyclization Sequence in Continuous Flow A. Steiner, R. C. Nelson, D. Dallinger, C. O. Kappe, Org. Process Res. Dev. 2022, 26, 2532–2539. DOI: 10.1021/acs.oprd.2c00214. |
| 179. | N-Hydroxyphthalimide Catalyzed Aerobic Oxidation of Aldehydes under Continuous Flow Conditions B. S. Nagy, C. O. Kappe, S. B. Ötvös, Adv. Synth. Catal. 2022, 364, 1998-2008. DOI: 10.1002/adsc.202200124. |
| 178. | Artificial Neural Networks and Data Fusion Enable Concentration Predictions for Inline Process Analytics P. Sagmeister, R. Hierzegger, J. D. Williams, C. O. Kappe, S. Kowarik, Digital Discovery 2022, 1, 405-412. DOI: 10.1039/D2DD00006G. |
| 177. | Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor J. Williams,P. Pöchlauer,Y. Okumura, Y. Inami, C. O. Kappe, Chem. Eur. J. 2022, 61, e202200741. DOI: 10.1002/chem.202200741. |
| 176. | Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow W. Jud, C. A. Salazar, J. Imbrogno, J. Verghese, S. M. Guinness, J.-N. Desrosiers, C. O. Kappe, D. Cantillo, Org. Process Res. Dev. 2022, 26, 1486-1495. DOI: 10.1021/acs.oprd.2c00064. |
| 175. | Automated Flow and Real-Time Analytics Approach for Screening Functional Group Tolerance in Heterogeneous Catalytic Reactions K. Simon, P. Sagmeister, R. Munday, K. Leslie, C. A. Hone, C. O. Kappe, Cat. Sci. Technol. 2022, 9, 1799-1811. DOI: 10.1039/D2CY00059H. |
| 174. | Autonomous Multi-Step and Multi-Objective Optimization Facilitated by Real-Time Process Analytics P. Sagmeister, F. F. Ort, C. E. Jusner, D. Hebrault, T. Tampone, F. G. Buono, J. D. Williams, C. O. Kappe, Adv. Sci. 2022, 12, 2105547. DOI: 10.1002/advs.202105547. |
| 173. | Practical Guidelines for the Safe Use of Fluorine Gas Employing Continuous Flow Technology D. Znidar, D. Dallinger, C. O. Kappe, ACS Chem. Health Saf. 2022, 29, 165-174. DOI: 10.1021/acs.chas.1c00097. |
| 172. | Enantioselective Flow Synthesis of Rolipram Enabled by a Telescoped Asymmetric Conjugate Addition−Oxidative Aldehyde Esterification Sequence using in Situ-Generated Persulfuric Acid as Oxidant B, Nagy, P. Llanes, M. Pericàs, C. O. Kappe, S. Ötvös, Org. Lett. 2022, 24, 1066–1071. DOI: 10.1021/acs.orglett.1c04300. |
| 171. | Chemoselective Electrochemical Oxidation of Secondary Alcohols using a Recyclable Chloride-Based Mediator F. Sommer, D. Cantillo, C. O. Kappe, Synlett 2022, 33, 166-170. DOI: 10.1055/a-1511-8869. |
| 170. | Automated and Continuous Synthesis of Drug Substances S. Sacher, I. Castillo, J. Rehrl, P. Sagmeister, R. Lebl, J. Kruisz, S. Celikovic, M. Sipek, J. D. Williams, D. Kirschneck, C. O. Kappe, M. Horn, Chem. Engin. Res. Design. 2022, 177, 493-501. DOI: 10.1016/j.cherd.2021.10.034. |
| 169. | Scalable Continuous Flow Hydrogenations Using Pd/Al2O3-coated Rectangular Cross-section 3D-printed Static Mixers R. Lebl, Y. Zhu, D. Ng, C. Hornung, D. Cantillo, C. O. Kappe, Catal. Today. 2022, 338, 55-63. DOI: 10.1016/j.cattod.2020.07.046. |
| 168. | N-Chloroamines as Substrates for Metal-free Photochemical Atom-transfer Radical Addition Reactions in Continuous Flow A. Steiner, O. de Frutos, J. A. Rincón, C. Mateos, J. Williams, C. O. Kappe, React. Chem. Eng. 2021, 6, 2434–2441. DOI: 10.1039/D1RE00429H. |
| 167. | A Small Footprint Oxycodone Generator Based on Continuous Flow Technology and Real-time Analytics F. Sommer, D. Cantillo, C. O. Kappe, J. Flow. Chem. 2021, 11, 707-715. DOI: 10.1007/s41981-021-00193-y. |
| 166. | Continuous Flow Synthesis of a Blocked Polyisocyanate: Process Intensification, Reaction Monitoring via In-line FTIR Analysis and Comparative Life Cycle Assessment G. Glotz, K. Waniek, J.-P. Schöggl, D. Cantillo, C. Stueckler, A. Arzt, A. Gollner, R. Schipfer, R. J. Baumgartner, C. O. Kappe , Org. Process Res. Dev. 2021, 25, 2367-2379. DOI: 10.1021/acs.oprd.1c00329. |
| 165. | Process Intensification of Ozonolysis Reactions using Dedicated Microstructured Reactors D. Polterauer, D. M. Roberge, P. Hanselmann, P. Elsner, C. A. Hone, C. O. Kappe, React. Chem. Eng. 2021, 6, 2253-2258. DOI: 10.1039/D1RE00264C. |
| 164. | Telescoped Lithiation, C-Arylation and Methoxylation in Flow-Batch Hybrid toward the Synthesis of Canagliflozin D. Polterauer, J. D. Williams, C. A. Hone, C. O. Kappe, Tetrahedron Lett. 2021, 82, 153351. DOI: 10.1016/j.tetlet.2021.153351 |
| 163. | Electrochemical α-Arylation of Ketones via Anodic Oxidation of in situ Generated Silyl Enol Ethers W. Jud, F. Sommer, C. O. Kappe, D. Cantillo, J. Org. Chem. 2021, 86, 16026-16034. DOI: 10.1021/acs.joc.1c01224. |
| 162. | Catalytic Static Mixer-Enabled Hydrogenation of a Key Fenebrutinib Intermediate: Real-time Analysis for a Stable and Scalable Process R. Lebl, S. Bachmann, P. Tosatti, J. Sedelmeier, K. Püntener, J. D. Williams, C. O. Kappe, Org. Process Res. Dev. 2021, 25, 1988-1995. DOI: 10.1021/acs.oprd.1c00258. |
| 161. | Continuous Flow Heterogeneous Catalytic Reductive Aminations under Aqueous Micellar Conditions Enabled by an Oscillatory Plug Flow Reactor M. Wernik, G. Sipos, B. Buchholcz, F. Darvas, Z. Novák, S. B. Ötvös, C. O. Kappe, Green Chem. 2021, 23, 5625-5632. DOI: 10.1039/D1GC02039K. |
| 160. | Comparative Life Cycle Assessment of Different Production Processes for Waterborne Polyurethane Dispersions V. Klug, J.-P. Schöggl, D. Dallinger, K. Hiebler, C. Stückler, A. Steiner, A. Arzt, C. O. Kappe, R. J. Baumgartner, ACS Sustain. Chem. Eng. 2021, 9, 8980-9889. DOI: 10.1021/acssuschemeng.1c01359. |
| 159. | A Continuous Flow Bromodimethylsulfonium Bromide Generator: Application to the Synthesis of 2-Arylaziridines from Styrenes M. Prieschl, D. Cantillo, C. O. Kappe, J. Flow. Chem. 2021, 11, 117-125. DOI: 10.1007/s41981-020-00125-2. |
| 158. | Intensified Continuous Flow Synthesis and Workup of 1,5-Disbustituted Tetrazoles Enhanced by Real-time Process Analytics P. Sagmeister, D. Kaldre, J. Sedelmeier, C. Moessner, K. Püntener, D. Kummli, J. D. Williams, C. O. Kappe, Org. Process Res. Dev. 2021, 25, 1206-1214. DOI: 10.1021/acs.oprd.1c00096. |
| 157. | Sustainable Aldehyde Oxidations in Continuous Flow Using in Situ-Generated Performic Acid M. Prieschl, S. Ötvös, C. O. Kappe, ACS Sustain. Chem. Eng. 2021, 9, 5519-5525. DOI: 10.1021/acssuschemeng.1c01668. |
| 156. | Sustainable Electrochemical Decarboxylative Acetoxylation of Aminoacids in Batch and Continuous Flow M. Köckinger, P. Hanselmann, D. Roberge, P. Geotti-Bianchini, C. O. Kappe, D. Cantillo, Green Chem. 2021, 23, 2382–2390. DOI: 10.1039/D1GC00201E. |
| 155. | A Flash Chemistry Approach to Organometallic C‑Glycosylation for the Synthesis of Remdesivir T. von Keutz, J. D. Williams, C. O. Kappe, Org. Process Res. Dev. 2021, 25, 1015-1021. DOI: 10.1021/acs.oprd.1c00024. |
| 154. | Synthesis of the Lipophilic Amine Tail of Abediterol Enabled by Multiphase Flow Transformations J. García-Lacuna, T. Fleiβ, R. Munday, K. Leslie, A. O’Kearney-McMullan, C. A. Hone, C. O. Kappe, Org. Process Res. Dev. 2021, 25, 947-959. DOI: 10.1021/acs.oprd.1c00002. |
| 153. | Cu-Catalyzed Aerobic Oxidation of Diphenyl Sulfide to Diphenyl Sulfoxide within a Segmented Flow Regime: Modeling of a Consecutive Reaction Network and Reactor Characterization G. Vernet, M.-S. Salehi, P. Lopatka, S. K. Wilkinson, S. K. Bermingham, R. Munday, A. O’Kearney-McMullan, K. Leslie, C. A. Hone, C. O. Kappe, Chem. Eng. J. 2021, 416, 129045. DOI: 10.1016/j.cej.2021.129045. |
| 152. | One-Pot Multistep Electrochemical Strategy for the Modular Synthesis of Epoxides, Glycols and Aldehydes from Alkenes W. Jud, C. O. Kappe, D. Cantillo, Electrochem. Sci. Adv. 2021, 1, e2100002. DOI: 10.1002/elsa.202100002. |
| 151. | Electrochemically Enabled One‐Pot Multistep Synthesis of C19 Androgen Steroids F. Sommer, C. O. Kappe, D. Cantillo, Chem. Eur. J. 2021, 27, 6044-6049. DOI: 10.1002/chem.202100446. |
| 150. | Advanced Real-Time Process Analytics for Multistep Synthesis in Continuous Flow P. Sagmeister, R. Lebl, I. Castillo, J. Rehrl, J. Kruisz, M. Sipek, M. Horn, S. Sacher, D. Cantillo, J. D. Williams, C. O. Kappe, Angew. Chem. Int. Ed. 2021, 60, 8139-8148. DOI: 10.1002/anie.202016007. |
| 149. | Flow Technology for Telescoped Generation, Lithiation and Electrophilic (C3) Functionalization of Highly Strained 1-Azabicyclo[1.1.0]butanes P. Musci, T. von Keutz, F. Belaj, L. Degennaro, D. Cantillo, C. O. Kappe, R. Luisi, Angew. Chem. Int. Ed. 2021, 60, 6395-6399. DOI: 10.1002/anie.202014881. |
| 148. | Development and Assembly of a Flow Cell for Single-Pass Continuous Electroorganic Synthesis Using Laser-Cut Components W. Jud, C. O. Kappe, D. Cantillo, Chem. Methods 2021, 1, 36-42. DOI: 10.1002/cmtd.202000042. |
| 147. | Continuous Flow Processing of Bismuth-photocatalyzed Atom Transfer Radical Addition Reactions Using an Oscillatory Flow Reactor P. Bianchi, J. D. Williams, C. O. Kappe, Green Chem. 2021, 23, 2685-2693. DOI: 10.1039/D0GC03070H. |
| 146. | Continuous On Demand Generation of Acrolein from Glycerol using a Reactive Distillation Strategy F. J. Strauss, P. Pöchlauer, C. Schuster, P. Kohls, S. Steinhofer, C. Zinganell, B. Gutmann, D. Cantillo, C. O. Kappe, Chim. Oggi/Chem. Today 2020, 38(6), 24-26. |
| 145. | On the Regioselectivity of the Gould−Jacobs Reaction: Gas‐phase versus Solution‐phase Thermolysis M. Wernik, P. E. Hartmann, G. Sipos, F. Darvas, A. D. Boese, D. Dallinger, C. O. Kappe, Eur. J. Org. Chem. 2020, 26, 7051-7061. DOI: 10.1002/ejoc.202001110. |
| 144. | A High-Yielding Synthesis of EIDD-2801 from Uridine A. Steiner, D. Znidar, S. B. Ötvös, D. R. Snead, D. Dallinger, C. O. Kappe, Eur. J. Org. Chem. 2020, 26, 6736-6739. DOI: 10.1002/ejoc.202001340. |
| 143. | Continuous Flow Synthesis of Arylhydrazines via Nickel/photoredox Coupling of tert-butyl carbazate with aryl halides A. Mata, D. N Tran, U. Weigl, J. Williams, C. O. Kappe, Chem. Commun. 2020, 56, 14621-14624. DOI: 10.1039/D0CC06787C. |
| 142. | A Novel Pathway for the Thermolysis of N-Nitrosoanthranilates using Flash Vacuum Pyrolysis leading to 7-Aminophthalides D. Zlatković, D. Dallinger, C. O. Kappe, Org. Biomol. Chem. 2020, 18, 8371–8375. DOI: 10.1039/D0OB01946A. |
| 141. | Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut and Fluorophenibut S. Ötvös, P. Llanes, M. Pericàs, C. O. Kappe, Org. Lett. 2020, 22, 8122−8126. DOI: 10.1021/acs.orglett.0c03100. |
| 140. | Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib M. Kockinger, B. Wyler, C. Aellig, D. M. Roberge, C. A. Hone, C. O. Kappe Org. Process Res. Dev. 2020, 24, 2217−2227. DOI: 10.1021/acs.oprd.0c00254. |
| 139. | Continuous Flow C-Glycosylation via Metal-Halogen Exchange – Process Understanding and Improvements toward Efficient Manufacturing of Remdesivir T. von Keutz, J. D. Williams, C. O. Kappe Org. Process Res. Dev. 2020, 24, 2362−2368. DOI: 10.1021/acs.oprd.0c00370. |
| 138. | Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates T. von Keutz, D. Cantillo, C. O. Kappe, Org. Lett. 2020, 22, 7537−7541. DOI: 10.1021/acs.orglett.0c02725. |
| 137. | Optimization and Sustainability Assessment of a Continuous Flow Ru-catalyzed Ester Hydrogenation for an Important Precursor of a ß2-Adrenergic Receptor Agonist M. Prieschl, J. García-Lacuna, R. Munday, K. Leslie, A. O’Kearney-McMullan, C. A. Hone, C. O. Kappe, Green Chem. 2020, 22, 448-454. DOI: 10.1039/D0GC02225J. |
| 136. | Electrochemical N‑Demethylation of 14-Hydroxy Morphinans: Sustainable Access to Opioid Antagonists G. Glotz, D. Cantillo, C. O. Kappe, Org. Lett. 2020, 22, 6891-6896. DOI: 10.1021/acs.orglett.0c02424. |
| 135. | Multi-kilogram per Hour Continuous Photochemical Benzylic Brominations Applying a Smart Dimensioning Scale-up Strategy A. Steiner, P. M. C. Roth, F. J. Strauss, G. Gauron, G. Tekautz, M. Winter, J. D. Williams, C. O. Kappe Org. Process Res. Dev. 2020, 24, 2208−2216. DOI: 10.1021/acs.oprd.0c00239. |
| 134. | A Modular 3D Printed Calorimeter for Reaction Calorimetry in Continuous Flow M. C. Maier, M. Leitner, C. O. Kappe, H. Gruber-Wölfler, React. Chem. Eng. 2020, 5, 1410-1420. DOI: 10.1039/D0RE00122H. |
| 133. | A Continuous Flow Cell for High Temperature/High Pressure Electroorganic Synthesis W. Jud, C. O. Kappe, D. Cantillo, ChemElectroChem 2020, 7, 2777–2783. DOI: 10.1002/celc.202000696. |
| 132. | Continuous flow synthesis of aryl aldehydes by Pd-catalyzed formylation of phenol-derived aryl fluorosulfonates using syngas M. Köckinger, P. Hanselmann, G. Hu, C. A. Hone, C. O. Kappe RSC Adv. 2020, 10, 22449–22453. DOI: 10.1039/d0ra04629a. |
| 131. | Translating Batch Electrochemistry to Single-Pass Continuous Flow Conditions: An Organic Chemist’s Guide S. Maljuric, W. Jud, C. O. Kappe, D. Cantillo, J. Flow. Chem. 2020, 10, 181-190. DOI: 10.1007/s41981-019-00050-z. |
| 130. | Acyl Azide Generation and Amide Bond Formation in Continuous-flow for the Synthesis of Peptides A. Mata, U. Weigl, O. Flögel, P. Baur, C. A. Hone, C. O. Kappe React. Chem. Eng. 2020, 5, 645-650. DOI: 10.1039/D0RE00034E. |
| 129. | Multivariate Analysis of Inline Benchtop NMR Data Enables Rapid Optimization of a Complex Nitration in Flow P. Sagmeister, J. Poms, J. D. Williams, C. O. Kappe, React. Chem. Eng. 2020, 5, 677-684. DOI: 10.1039/D0RE00048E. |
| 128. | Continuous Flow Synthesis of ZIF-8 Biocomposites with Tuneable Particle Size F. Carraro, J. D. Williams, M. Linares-Moreau, C. Parise, W. Liang, H. Amenitsch, C. Doonan, C. O. Kappe, P. Falcaro, Angew. Chem. Int. Ed. 2020, 59, 8123-8127. DOI: 10.1002/anie.202000678. |
| 127. | Phase Dependent Encapsulation and Release Profile of ZIF-based Biocomposites F. Carraro, M. de J. Velasquez-Hernandez, E. Astria, W. Liang, L. Twight, C. Parise, M. Ge, Z. Huang, R. Ricco, X. Zou, L. Villanova, C. O. Kappe, C. J Doonan, P. Falcaro, Chem. Sci. 2020, 11, 3397-3404. DOI: 10.1039/C9SC05433B. |
| 126. | An Oscillatory Plug Flow Photoreactor Facilitates Semi-heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C-N Couplings C. Rosso, S. Gisbertz, J. D. Williams, H. P. L. Gemoets, W. Debrouwer, B. Pieber, C. O. Kappe, React. Chem. Eng. 2020, 5, 597-604. DOI: 10.1039/D0RE00036A. |
| 125. | Organophotocatalytic N-Demethylation of Oxycodone using Molecular Oxygen Y. Chen, G. Glotz, D. Cantillo, C. O. Kappe, Chem. Eur. J. 2020, 26, 2973-2979. DOI: 10.1002/chem.201905505. |
| 124. | Continuous Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex S. B. Ötvös, C. O. Kappe, ChemSusChem 2020, 13, 1800-1807. DOI: 10.1002/cssc.201903459. |
| 123. | Continuous Photochemical Benzylic Bromination Using in situ Generated Br2: Process Intensification towards Optimal PMI and Throughput A. Steiner, J. D. Williams, O. de Frutos, J. A. Rincón, C. Mateos, C. O. Kappe, Green Chem. 2020, 22, 448-454. DOI: 10.1039/C9GC03662H. |
| 122. | Continuous Flow Synthesis of Terminal Epoxides from Ketones using in Situ-Generated Bromomethyl Lithium T. von Keutz, D. Cantillo, C. O. Kappe, Org. Lett. 2019, 21, 10094-10098. DOI: 10.1021/acs.orglett.9b04072. |
| 121. | Continuous Flow Synthesis of Methyl Oximino Acetoacetate: Accessing Greener Purification Methods with Inline Liquid-Liquid Extraction and Membrane Separation Technology R. Lebl, T. Murray, A. Adamo, D. Cantillo, C. O. Kappe, ACS Sustain. Chem. Eng. 2019, 7, 20088-20096. DOI: 10.1021/acssuschemeng.9b05954. |
| 120. | Multigram-Scale Flow Synthesis of the Chiral Key Intermediate of (–)-Paroxetine Enabled by Solvent-Free Heterogeneous Organocatalysis S. B. Ötvös, M. A. Pericas, C. O. Kappe, Chem. Sci. 2019, 10, 11141-11146. DOI: 10.1039/C9SC04752B. |
| 119. | Oxygen Sensors for Flow Reactors – Measuring Dissolved Oxygen in Organic Solvents P. Sulzer, R. Lebl, C. O. Kappe, T. Mayr, React. Chem. Eng. 2019, 4, 2081-2087. DOI: 10.1039/C9RE00253G. |
| 118. | Scalable Wolff-Kishner Reductions in Extreme Process Windows Using a Silicon Carbide Flow Reactor D. Znidar, A. O´Kearney-McMullan, R. Munday, C. Wiles, P. Poechlauer, C. Schmoelzer, D. Dallinger, C. O. Kappe, Org. Process Res. Dev. 2019, 23, 2445-2455. DOI: 10.1021/acs.oprd.9b00336. |
| 117. | Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an In Situ Generated Triflyltriethylammonium Complex W. Jud, S. Maljuric, C. O. Kappe, D. Cantillo, Org. Lett. 2019, 21, 7970-7975. DOI: 10.1021/acs.orglett.9b02948. |
| 116. | Implementing Hydrogen Atom Transfer (HAT) Catalysis for Rapid and Selective Reductive Photoredox Transformations in Continuous Flow A. Steiner, J.D. Williams, J. A Rincón, O. de Frutos, C. Mateos, C. O. Kappe, Eur. J. Org. Chem. 2019, 25, 5807-5811. DOI: 10.1002/ejoc.201900952. |
| 115. | Visible Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and its Application to the Synthesis of a Key Fulvestrant Intermediate C. Rosso, J. D. Williams, G. Filippini, M. Prato, C. O. Kappe, Org. Lett. 2019, 21, 5341-5345. DOI: 10.1021/acs.orglett.9b01992. |
| 114. | HCN on Tap: On-Demand Continuous Production of Anhydrous HCN for Organic Synthesis M. Köckinger, C. A. Hone, C. O. Kappe, Org. Lett. 2019, 21, 5326-5330. DOI: 10.1021/acs.orglett.9b01941. |
| 113. | Design and Optimization of a CSTR Cascade for Membrane-based Diazomethane Production – Synthesis of α-Chloroketones M. Wernik, P. Poechlauer, C. Schmoelzer, D. Dallinger, C. O. Kappe, Org. Process Res. Dev. 2019, 23, 1359-1368. DOI: 10.1021/acs.oprd.9b00115. |
| 112. | Laboratory of the Future: A Modular Flow Platform with Multiple Integrated PAT Tools for Multistep Reactions P. Sagmeister, J. D. Williams, C. A. Hone, C. O. Kappe, React. Chem. Eng. 2019, 4, 1571-1578. DOI: 10.1039/C9RE00087A. |
| 111. | On the Reactivity of Anodically Generated Trifluoromethyl Radicals Toward Aryl Alkynes in Organic/Aqueous Media W. Jud, C. O. Kappe, D. Cantillo, Org. Biomol. Chem. 2019, 17, 1384-1388. DOI: 10.1039/C9OB00456D. |
| 110. | Visible Light-Promoted Beckmann Rearrangements: Separating Sequential Photochemical and Thermal Phenomena in a Continuous Flow Reactor Y. Chen, D. Cantillo, C. O. Kappe, Eur. J. Org. Chem. 2019, 25, 2163–2171. DOI: 10.1002/ejoc.201900231. |
| 109. | Towards a Scalable Synthesis of 2-Oxabicyclo[2.2.0]hex-5-en-3-one Using Flow Photochemistry J. D. Williams; Y. Otake; G. Coussanes; I. Saridakis; N. Maulide, C. O. Kappe, ChemPhotoChem 2019, 3, 229-232. DOI: 10.1002/cptc.201900017. |
| 108. | Continuous Generation, In-line Quantification and Utilization of Nitrosyl Chloride in Photonitrosation Reactions R. Lebl, D. Cantillo, C. O. Kappe, React. Chem. Eng. 2019, 4, 738–746. DOI: 10.1039/C8RE00323H. |
| 107. | Photochemical Benzylic Bromination in Flow using BrCCl3 and its Application to Telescoped p-Methoxybenzyl Protection Y. Otake, J. D. Williams, J. A. Rincón, O. de Frutos, C. Mateos, C. O. Kappe, Org. Biomol. Chem. 2019, 17, 1384-1388. DOI: 10.1039/C9OB00044E. |
| 106. | A Continuous-flow Protocol for the Synthesis of Enantiomerically Pure Intermediates of Anti Epilepsy and Anti Tuberculosis Active Pharmaceutical Ingredients R. M. Aguiar, R. A. C. Leão, A. Mata-Gomez, D. Cantillo, C. O. Kappe, L. S. M. Miranda, R. O. M. A. de Souza, Org. Biomol. Chem. 2019, 17, 1552-1557. DOI: 10.1039/C8OB03088J. |
| 105. | Finding the Perfect Match: A Combined Computational and Experimental Study Towards Efficient and Scalable Photosensitized [2+2] Cycloadditions in Flow J. D. Williams, M. Nakano, G. Romaric, J. A. Rincon, O. de Frutos, C. Mateos, J. C. M. Monbaliu, C. O. Kappe, Org. Process Res. Dev. 2019, 23, 78-87. DOI: 10.1021/acs.oprd.8b00375. |
| 104. | Continuous-flow Pd-catalyzed Carbonylation of Aryl Chlorides with Carbon Monoxide at Elevated Temperature and Pressure A. Mata, C. A. Hone, B. Gutmann, L. Moens, C. O. Kappe, ChemCatChem 2019, 11, 997-1001. DOI: 10.1002/cctc.201801974. |
| 103. | Enhanced Mixing of Biphasic Liquid-Liquid Systems for the Synthesis of gem-Dihalocyclopropanes using Packed Bed Reactors T. von Keutz, D. Cantillo, C. O. Kappe, J. Flow. Chem. 2019, 9, 27-34. DOI: 10.1007/s41981-018-0026-1. |
| 102. | Development of Customized 3D Printed Stainless Steel Reactors with Inline Oxygen Sensors for Aerobic Oxidation of Grignard Reagents in Continuous Flow M. C. Maier, R. Lebl, P. Sulzer, J. Lechner, T. Mayr, M. Zadravec, E. Slama, S. Pfanner, C. Schmölzer, P. Pöchlauer, C. O. Kappe, H. Gruber-Woelfler, React. Chem. Eng. 2019, 4, 393-401. DOI:10.1039/C8RE00278A. |
| 101. | Continuous-flow Synthesis of Aryl Aldehydes by Pd-catalyzed Formylation of Aryl Bromides Using Carbon Monoxide and Hydrogen C. A. Hone, P. Lopatka, R. Munday, A. O’Kearney-McMullan, C. O. Kappe, ChemSusChem 2019, 12, 326-337. DOI: 10.1002/cssc.201802261. |
| 100. | Scalable Continuous Flow Process for the Synthesis of Eflornithine using Fluoroform as Difluoromethyl Source M. Köckinger, C. A. Hone, B. Gutmann, P. Hanselmann, M. Bersier, A. Torvisco, C. O. Kappe, Org. Process Res. Dev. 2018, 22, 1553–1563. DOI: 10.1021/acs.oprd.8b00318. |
| 99. | Catalyst Free Oxytrifluoromethylation of Alkenes via Paired Electrolysis in Organic-Aqueous Media W. Jud, C. O. Kappe, D. Cantillo, Chem. Eur. J. 2018, 24, 17234-17238. DOI: 10.1002/chem.201804708. |
| 98. | Continuous Flow Photochemical Benzylic Bromination of a Key Intermediate in the Synthesis of a 2-Oxazolidinone Y. Chen, O. de Frutos, C. Mateos, J. A. Rincon, D. Cantillo, C. O. Kappe, ChemPhotoChem 2018, 2, 906-912. DOI: 10.1002/cptc.201800114. |
| 97. | Sequential α-Lithiation and Aerobic Oxidation of an Arylacetic Acid – Continuous-flow Synthesis of Cyclopentyl Mandelic Acid S. De Angelis, C. A. Hone, L. Degennaro, P. Celestini, R. Luisi, C. O. Kappe, J. Flow. Chem. 2018, 8, 109–116. DOI: 10.1007/s41981-018-0015-4. |
| 96. | Design and Construction of an Open Source-Based Photometer and its Applications in Flow Chemistry G. Glotz, C. O. Kappe, React. Chem. Eng. 2018, 3, 478-486. 10.1039/C8RE00070K. |
| 95. | Process Intensification and Integration Studies for the Generation of a Key Aminoimidazole Intermediate in the Synthesis of Lanabecestat D. Znidar, D. Cantillo, P. Inglesby, A. Boyd, C. O. Kappe, Org. Process Res. Dev. 2018, 22, 633-640. DOI: 10.1021/acs.oprd.8b00089. |
| 94. | Continuous Multistep Synthesis of 2-(Azidomethyl)oxazoles T. A. Rossa, N. S. Suveges, M. M. Sá, D. Cantillo, C. O. Kappe, Beilstein J. Org. Chem 2018, 14, 506-514. doi:10.3762/bjoc.14.36. |
| 93. | Continuous Flow Multistep Synthesis of α-Functionalized Esters via Lithium Enolate Intermediates T. von Keutz, F. J. Strauss, D. Cantillo, C. O. Kappe, Tetrahedron 2018, 74, 3113-3117. DOI:10.1016/j.tet.2017.11.063. |
| 92. | Utilization of Fluoroform for Difluoromethylation in Continuous Flow: A Concise Synthesis of α-Difluoromethylamino Acids M. Köckinger, T. Ciaglia, M. Bersier, P. Hanselmann, B. Gutmann, C. O. Kappe, Green Chem. 2018, 20, 108-112. DOI:10.1039/C7GC02913F. |
| 91. | Design and 3D Printing of a Stainless Steel Reactor for Continuous Difluoromethylations Using Fluoroform B. Gutmann, M. Köckinger, G. Glotz, T. Ciaglia, E. Slama, M. Zadravec, S. Pfanner, M. C. Maier, H. Gruber-Wölfler, C. O. Kappe, React. Chem. Eng. 2017, 2, 919-927. DOI:10.1039/C7RE00176B. |
| 90. | Generation of Anhydrous Diazomethane on Lab Scale using Membrane Separation Technology D. Dallinger, C. O. Kappe, Nature Prot. 2017, 12, 2138-2147. DOI:10.1038/nprot.2017.046. |
| 89. | Integration of Bromine and Cyanogen Bromide Generators for the Telescoped Continuous Synthesis of Cyclic Guanidines G. Glotz, R. Lebl, D. Dallinger, C. O. Kappe, Angew. Chem. Int. Ed. 2017, 56, 13786 –13789. DOI: 10.1002/anie.201708533 . |
| 88. | Synthesis of Mepivacaine and its Analogues by a Continuous Flow Tandem Hydrogenation−Reductive Amination Strategy N.S. Suveges, R. O. M. A. de Souza, B. Gutmann, C. O. Kappe, Eur. J. Org. Chem. 2017, 24, 6511-6517. DOI: 10.1002/ejoc.201700824. |
| 87. | An Integrated Continuous Flow Synthesis of a Key Oxazolidine Intermediate to Noroxymorphone from Naturally Occurring Opioids A. Mata, D. Cantillo, C. O. Kappe, Eur. J. Org. Chem. 2017, 24, 6505-6510. DOI: 10.1002/ejoc.201700811. |
| 86. | Continuous Flow Synthesis of Carbonylated Heterocycles via Pd-Catalyzed Oxidative Carbonylation Using CO and O2 at Elevated Temperature and Pressure Y. Chen, C. A. Hone, B. Gutmann, C. O. Kappe, Org. Process Res. Dev. 2017, 21, 1080-1087. DOI: 10.1021/acs.oprd.7b00217. |
| 85. | Development of a Continuous-Flow Sonogashira Cross-Coupling Protocol using Propyne Gas under Process Intensified Conditions D. Znidar, C. A. Hone, P. Inglesby, A. Boyd, C. O. Kappe, Org. Process Res. Dev. 2017, 21, 878-884. DOI: 10.1021/acs.oprd.7b00160. |
| 84. | Development of a Continuous-Flow Process for a Pd-Catalyzed Olefin Cleavage using Oxygen within the Explosive Regime C. A. Hone, A. O’Kearney-McMullan, R. Munday, C. O. Kappe, ChemCatChem 2017, 9, 3298 – 3302. DOI: 10.1002/cctc.201700671. |
| 83. | Continuous Flow Difluoromethylation with Chlorodifluoromethane under Biphasic Conditions B. Gutmann, P. Hanselmann, M. Bersier, D. Roberge, C. O. Kappe, J. Flow. Chem. 2017, 7, 46-51. DOI: 10.1556/1846.2017.00005 . |
| 82. | Hydrogen Sulfide Chemistry in Continuous Flow: Efficient Synthesis of 2-Oxopropanethioamide D. Cantillo, P. A. Inglesby, A. Boyd, C. O. Kappe, J. Flow. Chem. 2017, 7, 29-32. DOI: 10.1556/1846.2017.00006. |
| 81. | Reaction Calorimetry in Microreactor Environments – Measuring Heat of Reaction by Isothermal Heat Flux Calorimetry G. Glotz, D. Knoechel, P. Podmore, H. Gruber-Woelfler, C. O. Kappe, Org. Process Res. Dev. 2017, 21, 763-770. DOI: 10.1021/acs.oprd.7b00092. |
| 80. | Continuous Flow Synthesis of Indoles by Pd-catalyzed Deoxygenation of 2-Nitrostilbenes with Carbon Monoxide G. Glotz, B. Gutmann, P. Hanselmann, A. Kulesza, D. Roberge, C. O. Kappe, RSC Adv. 2017, 7, 10469-10478. DOI: 10.1039/c7ra01087g. |
| 79. | Continuous Flow Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization Sequence D. Cantillo, B. Wolf, R. Goetz, C. O. Kappe, Org. Process Res. Dev. 2017, 21, 125-132. DOI: 10.1021/acs.oprd.6b00409. |
| 78. | Design and Development of Pd-catalyzed Aerobic N-Demethylation Strategies for the Synthesis of Noroxymorphone in Continuous Flow Mode B. Gutmann, D. Cantillo, U. Weigl, D. P. Cox, C. O. Kappe, Eur. J. Org. Chem. 2017, 914-927. DOI: 10.1002/ejoc.201601453. |
| 77. | Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals – A Fast and Scalable Protocol for Trifluoromethylation J. L. Monteiro, P. F. Carneiro, P. Elsner, D. Roberge, P. G. M. Wuts, K. Kurjan, B. Gutmann, C. O. Kappe, Chem. Eur. J. 2017, 23, 176-186. DOI: 10.1002/chem.201604579 (selected as ”Hot Paper” by the Editors). |
| 76. | Design and Performance Validation of a Conductively Heated Sealed-Vessel Reactor for Organic Synthesis D. Obermayer, D. Znidar, G. Glotz, A. Stadler, D. Dallinger, C. O. Kappe, J. Org. Chem. 2016, 81, 11788-11801. DOI: 10.1021/acs.joc.6b02242. |
| 75. | Continuous-Flow Electrophilic Amination of Arenes and Schmidt Reaction of Carboxylic Acids Utilizing the Superacidic Trimethylsilyl Azide/Triflic Acid Reagent System Y. Chen, B. Gutmann, C. O. Kappe, J. Org. Chem. 2016, 81, 9372-9380. DOI: 10.1021/acs.joc.6b02085. |
| 74. | A Laboratory-Scale Continuous Flow Chlorine Generator for Organic Synthesis F. J. Strauss, D. Cantillo, J. Guerra, C. O. Kappe, React. Chem. Eng. 2016, 1, 472-476. DOI; 10.1039/c6re00135a. (highlighted by Chemistry World) |
| 73. | One-Pot Synthesis of alpha-Haloketones Employing a Membrane-Based Semi-Batch Diazomethane Generator S. Garbarino, J. Guerra, P. Poechlauer, B. Gutmann, C. O. Kappe, J. Flow Chem. 2016, 6, 211-217. DOI: 10.1556/1846.2015.00046. |
| 72. | Towards the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N-Demethylation Strategies B. Gutmann, P. Elsner, D. P. Cox, U. Weigl, D. M. Roberge, C. O. Kappe, ACS Sust. Chem. Eng. 2016, 4, 6048-6061. DOI: 10.1021/acssuschemeng.6b01371 (invited contribution for special issue: Building on 25 Years of Green Chemistry and Engineering for a Sustainable Future) |
| 71. | A Laboratory Scale Reactor for the Generation of Anhydrous Diazomethane D. Dallinger, V. D. Pinho, B. Gutmann, C. O. Kappe, J. Org. Chem. 2016, 81, 5814-5823. DOI:10.1021/acs.joc.6b01190 (selected as “Featured Article” by the Editors). |
| 70. | Batch and Continuous Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines – A Concise Synthesis of Noroxymorphone B. Gutmann, U. Weigl, D. P. Cox, C. O. Kappe, Chem. Eur. J. 2016, 22, 10393-10398. DOI:10.1002/chem.201601902 (selected as ”Hot Paper” by the Editors). |
| 69. | Visible-Light Photoredox Catalysis using a Macromolecular Ruthenium Complex: Reactivity and Recovery by Size-Exclusion Nanofiltration in Continuous Flow J. Guerra, D. Cantillo, C. O. Kappe, Catal. Sci. Technol. 2016, 6, 4695-4699. DOI: 10.1039/c6cy00070c |
| 68. | Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies B. Pieber, C. O. Kappe, Org. Lett. 2016, 18, 1076−1079. DOI: 10.1021/acs.orglett.6b00194 |
| 67. | Selective Olefin Reduction in Thebaine Using Hydrazine Hydrate and O2 under Intensified Continuous Flow Conditions B. Pieber, D. P. Cox, C. O. Kappe, Org. Process Res. Dev. 2016, 20, 376−385. DOI: 10.1021/acs.oprd.5b00370 (invited contribution for special issue: Continuous Processing, Microreactors and Flow Chemistry). |
| 66. | Copper/Nafion-Catalyzed Hydroarylation Process Involving Ketenimine Intermediates: A Novel and Synthetic Approach to 4-Sulfonamidoquinoline-2-ones and Derivatives Thereof B. Reichart, G. Guedes de la Cruz, K. Zangger, C. O. Kappe, T. Glasnov, Adv. Synth. Catal. 2016, 358, 50–55. DOI: 10.1002/adsc.201500942 |
| 65. | Safe Generation and Use of Bromine Azide under Continuous Flow Conditions ̶ Selective 1,2-Bromoazidation of Olefines D. Cantillo, B. Gutmann, C. O. Kappe, Org. Biomol. Chem. 2016, 14, 853-857. DOI: 10.1039/c5ob02425k |
| 64. | Continuous Synthesis of Hydantoins: Intensifying the Bucherer-Bergs Reaction J. L. Monteiro, B. Pieber, A. G. Corrêa, C. O. Kappe, Synlett 2016, 27, 83-87. DOI: 10.1055/s-0035-1560317 |
| 63. | Continuous Flow Preparation of Supported Iron Oxide Nanoparticles on Porous Silicates A. Yepez, F. L.Y. Lam, A. A. Romero, C. O. Kappe, R. Luque, ChemCatChem 2015, 7, 276–282. DOI: 10.1002/cctc.201402802 |
| 62. | Singlet Oxygen Oxidation of 5-Hydroxymethylfurfural (5-HMF) in Continuous Flow T. S. A. Heugebaert, C. V. Stevens, C. O. Kappe, ChemSusChem 2015, 8, 1648-1651. DOI: 10.1002/cssc.201403182 |
| 61. | Continuous Flow Reduction of Artemisinic Acid Utilizing Multi-Injection Strategies – Closing the Gap Towards a Fully Continuous Synthesis of Antimalarial Drugs B. Pieber, T. Glasnov, C. O. Kappe, Chem. Eur. J. 2015, 21, 4368-4376. DOI: 10.1002/chem.201406439 (selected as “Hot Paper“ by the Editors, covered by Chemical & Engineering News). |
| 60. | Benchmarking Immobilized Di- and Triarylphosphine Palladium Catalysts for Continuous Flow Cross-Coupling Reactions: Efficiency, Durability and Metal Leaching Studies R. Greco, W. Goessler, D. Cantillo, C. O. Kappe, ACS Catal. 2015, 5, 1303-1312. DOI: 10.1021/cs5020089 |
| 59. | Nafion-H Catalyzed High-Temperature/High-Pressure Synthesis of a Triarylmethane in Continuous Flow Mode S. Hayden, T. Glasnov, C. O. Kappe, Chem. Eng. Technol. 2015, 5, 1303-1312. DOI: 10.1002/ceat.201400581 |
| 58. | A Sequential Ugi Multicomponent/Cu-Catalyzed Azide-Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic Peptoids C. E. M. Salvador, B. Pieber, P. M. Neu, A. Torvisco, C. K. Z. Andrade, C. O. Kappe, J. Org. Chem. 2015, 80, 4590-4602. DOI: 10.1021/acs.joc.5b00445 |
| 57. | Light-Induced C−H Arylation of (Hetero)arenes via In Situ Generated Diazo Anhydrides D. Cantillo, C. Mateos , J. A. Rincon, O. de Frutos, C. O. Kappe, Chem. Eur. J. 2015, 21, 12894-12898. DOI: 10.1002/chem.201502357 |
| 56. | Development of a Continuous Flow Sulfoxide Imidation Protocol Using Azide Sources under Superacidic Conditions B. Gutmann, P. Elsner, A. O’Kearney-McMullan, W. Goundry, D. M. Roberge, C. O. Kappe, Org. Process Res. Dev. 2015, 19, 1062-1067. DOI: 10.1021/acs.oprd.5b00217 |
| 55. | Process Intensified Flow Synthesis of 1H-4-Substituted Imidazoles: Toward the Continuous Production of Daclatasvir P. F. Carneiro, B. Gutmann, R. O. M. A. de Souza, C. O. Kappe, ACS Sust. Chem. Eng. 2015, 3, 3445−3453. DOI: 10.1021/acssuschemeng.5b01191 |
| 54. | A Scalable Procedure for Light Induced Benzylic Brominations in Continuous Flow D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe, J. Org. Chem. 2014, 79, 223-229. DOI: 10.1021/jo402409k |
| 53. | Continuous Flow alpha-Trifluoromethylation of Ketones by Metal Free Visible Light Photoredox Catalysis D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos , C. O. Kappe, Org. Lett. 2014, 17, 5590-5593. DOI: 10.1021/ol403650y (Web of Science Highly Cited Article). |
| 52. | Continuous Flow Synthesis of alpha-Haloketones – Essential Building Blocks of Antiretroviral Agents V. D. Pinho, B. Gutmann, L. S. M. Miranda, R. O. M. A. de Souza, C. O. Kappe, J. Org. Chem. 2014, 79, 1555-1562. DOI: 10.1021/jo402849z (selected as “Featured Article” by the Editors). |
| 51. | Flash Carboxylation: Fast Lithiation – Carboxylation Sequence at Room Temperature in Continuous Flow B. Pieber, T. Glasnov, C. O. Kappe, RSC Adv. 2014, 4, 13430-13433. DOI: 10.1039/c4ra01442a |
| 50. | Combined Batch and Continuous Flow Procedure to the Chemo-Enzymatic Synthesis of Biaryl Moiety of Odanacatib R. de Oliveira Lopes, A. S. de Miranda, B. Reichart, T. Glasnov, C. O. Kappe, R. C. Simon, W. Kroutil, L. S. M. Miranda, I. C. R.Leal, R. O. M. A. de Souza, Mol. Catal. B. 2014, 104, 101-107. DOI: 10.1016/j.molcatb.2014.03.017 |
| 49. | Chemistry of Pyrrolizidine Alkaloids Revisited – Semi-Synthetic Microwave and Continuous-Flow Approaches towards Crotalaria-Alkaloids S. T. Martinez, A. C. Pinto, T. Glasnov, C. O. Kappe, Tetrahedron Lett. 2014, 55, 4181-4184. DOI: 10.1016/j.tetlet.2014.05.055 |
| 48. | A Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol − Safe Generation and Use of an Explosive Intermediate under Continuous Flow Conditions D. Cantillo, M. Damm, D. Dallinger, M. Bauser, M. Berger, C. O. Kappe, Org. Process Res. Dev. 2014, 18, 1360-1366. DOI: 10.1021/op5001435 (invited contribution for special issue: Continuous Processes 14) |
| 47. | Immobilized Iron Oxide Nanoparticles as Stable and Reusable Catalysts for Hydrazine-mediated Nitro Reductions in Continuous Flow M. Mirhosseini Moghaddam, B. Pieber, T. Glasnov, C. O. Kappe, ChemSusChem 2014, 7, 3122-3131. DOI: 10.1002/cssc.201402455 |
| 46. | Shifting Chemical Equilibria in Flow – Efficient Decarbonylation Chemistry Driven by Annular Flow Regimes B. Gutmann, P. Elsner, T. Glasnov, D. M. Roberge, C. O. Kappe, Angew. Chem. Int. Ed. 2014, 53, 11557-11561. DOI: 10.1002/anie.201407219 |
| 45. | Continuous Flow Synthesis of beta-Amino Acids from alpha-Amino Acids via Arndt-Eistert Homologation V. D. Pinho, B. Gutmann, C. O. Kappe, RSC Adv. 2014, 4, 37419-37422. DOI: 10.1039/c4ra08113g |
| 44. | A Continuous Flow Protocol for Light-Induced Benzylic Fluorination D. Cantillo, O. de Frutos, J. A. Rincon, C. Mateos, C. O. Kappe, J. Org. Chem. 2014, 79, 8486-8490. DOI: 10.1021/jo5016757 |
| 43. | Continuous Flow Synthesis of n-Alkyl Chlorides in a High-Temperature Microreactor Environment B. Reichart, G. Tekautz, C. O. Kappe, Org. Process Res. Dev. 2013, 17, 152-156. DOI: 10.1021/op300273u |
| 42. | Direct Aerobic Oxidation of 2-Benzylpyridines in a Gas-Liquid Continuous-Flow Regime Using Propylene Carbonate as Solvent B. Pieber, C. O. Kappe, Green Chem. 2013, 15, 320-324. DOI: 10.1039/c2gc36896j |
| 41. | On the Fischer Indole Synthesis of 7-Ethyltryptophol- Mechanistic and Process Intensification Studies under Continuous Flow Conditions B. Gutmann, M. Gottsponer, P. Elsner, D. Cantillo, D. M. Roberge, C. O. Kappe, Org. Process Res. Dev. 2013, 17, 294-302. DOI: 10.1021/op300363s |
| 40. | Nanocatalysis in Continuous Flow: Supported Iron Oxide Nanoparticles for the Heterogeneous Aerobic Oxidation of Benzyl Alcohol D. Obermayer, A. M. Balu, A. A. Romero, W. Goessler, R. Luque, C. O. Kappe, Green Chem. 2013, 15, 1530-1537. DOI: 10.1039/c3gc40307f |
| 39. | Continuous Flow Synthesis of Adipic Acid from Cyclohexene Using Hydrogen Peroxide in High-Temperature Explosive Regimes M. Damm, B. Gutmann, C. O. Kappe, ChemSusChem 2013, 6, 978-982. DOI: 10.1002/cssc.201300197 |
| 38. | Hydrazine-Mediated Reduction of Nitro and Azide Functionalities Catalyzed by Highly Active and Reusable Magnetic Iron Oxide Nanocrystals D. Cantillo, M. Mirhosseini Moghaddam, C. O. Kappe, J. Org. Chem. 2013, 78, 4530-4542. DOI: 10.1021/jo400556g |
| 37. | Continuous-flow Synthesis of CdSe Quantum Dots: A Size Tunable and Scalable Approach M. M. Moghaddam, M. Baghbanzadeh, A. Sadeghpour, O. Glatter, C. O. Kappe, Chem. Eur. J. 2013, 19, 11629-11636. DOI: 10.1002/chem.201301117 |
| 36. | Versatile Low-loaded Mechanochemically Synthesized Supported Iron Oxide Nanoparticles for Continuous Flow Alkylations A. M. Balu, A. Pineda, D. Obermayer, A. A. Romero, C. O. Kappe, R. Luque, RSC Adv. 2013, 3, 16292-16295. DOI: 10.1039/c3ra43160f |
| 35. | In Situ Generation of Diimide from Hydrazine and Oxygen – Transfer Hydrogenation of Olefins in Continuous Flow B. Pieber, S. T. Martinez, D. Cantillo, C. O. Kappe, Angew. Chem. Int. Ed. 2013, 52, 10241-10244. DOI: 10.1002/anie.201303528 |
| 34. | Continuous-flow Production of Photocatalytically Active Titanium Dioxide Nanocrystals and its Application to the Photocatalytic Addition of N,N-Dimethylaniline to N-Methylmaleimide M. Baghbanzadeh, T. N. Glasnov, C. O. Kappe, J. Flow Chem. 2013, 3, 109-113. DOI: 10.1556/JFC-D-13-00018 |
| 33. | A Three Step Continuous Flow Synthesis of the Biaryl Unit of the HIV Protease Inhibitor Atazanavir L. Dalla-Vechia, B. Reichart, T. N. Glasnov, L. S. M. Miranda, C. O. Kappe, R. O. M. A. de Souza, Org. Biomol. Chem. 2013, 11, 6806-6813. DOI: 10.1039/c3ob41464g |
| 32. | Phase-Transfer Catalysis – Mixing Effects in Continuous-Flow Liquid/Liquid O- and S-Alkylation Processes B. Reichart, C. O. Kappe, T. N. Glasnov, Synlett 2013, 24, 2393-2396. DOI: 10.1055/s-0033-1339839 |
| 31. | Direct Preparation of Nitriles from Carboxylic Acids in Continuous Flow D. Cantillo, C. O. Kappe, J. Org. Chem. 2013, 78, 10567-10571. DOI: 10.1021/jo401945r |
| 30. | Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF 2400 Tube-in-Tube Reactor F. Mastronardi, B. Gutmann, C. O. Kappe, Org. Lett. 2013, 16, 5590-5593. DOI: 10.1021/ol4027914 (covered by „In the Pipeline“ Blog) |
| 29. | Homogeneous Liquid-Phase Oxidation of Ethylbenzene to Acetophenone in Continuous Flow Mode B. Gutmann, P. Elsner, D. Roberge, C. O. Kappe, ACS Catal. 2013, 3, 2669-2676. DOI: 10.1021/cs400571y |
| 28. | High-Temperature Continuous Flow Synthesis of 1,3,4-Oxadiazoles via N-Acylation of 5-Substituted Tetrazoles B. Reichart, C. O. Kappe, Tetrahedron Lett. 2012, 53, 952-955. DOI: 10.1016/j.tetlet.2011.12.043 |
| 27. | Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe, J. Flow Chem. 2012, 2,8-19. DOI: 10.1556/jfchem.2012.00021 |
| 26. | Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environment D. Cantillo, H. Sheibani, C. O. Kappe, J. Org. Chem. 2012, 77, 2463-2473. DOI: 10.1021/jo3001645 |
| 25. | Copper-Catalyzed C-O Bond Formation by Direct a-C-H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous Flow Formats G. S. Kumar, B. Pieber, K. R. Reddy, C. O. Kappe, Chem. Eur. J. 2012, 18, 6124-6128. DOI: 10.1002/chem.201200815 |
| 24. | Microwave-assisted Continuous Flow Synthesis on Industrial Scale R. Morschhäuser, M. Krull, C. Kayser, C. Boberski, R. Bierbaum, P. A. Püschner, T. N. Glasnov, C. O. Kappe, Green Process. Synthesis 2012, 1, 281-290. DOI 10.1515/gps-2012-0032 |
| 23. | In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes in Continuous Flow. D. Cantillo, M. Baghbanzadeh, C. O. Kappe, Angew. Chem. Int. Ed. 2012, 51, 10190-10193. DOI: 10.1002/anie.201205792 (Web of Science Highly Cited Article). |
| 22. | Methylation Using Dimethylcarbonate Catalysed by Ionic Liquids Under Continuous Flow Conditions T. N. Glasnov, J. D. Holbrey, C. O. Kappe, K. R. Seddon, T. Yan, Green Chem. 2012, 14, 3071-3076. DOI: 10.1039/c2gc36226k |
| 21. | A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones M. Viviano, T. N. Glasnov, B. Reichart, G. Tekautz, C. O. Kappe, Org. Process Res. Dev. 2011, 15, 858-870. DOI: 10.1021/op2001047 |
| 20. | Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides D. Obermayer, T. N. Glasnov, C. O. Kappe, J. Org. Chem. 2011, 76, 6657-6669. DOI: 10.1021/jo2009824 |
| 19. | Microwave-assisted Grafting to MCM-41 Silica and its Application as Catalyst in Flow Chemistry M. Oliverio, A. Procopio, T. N. Glasnov, W. Goessler, C. O. Kappe, Aust. J. Chem. 2011, 64, 1522-1529. DOI: 10.1071/CH11125 |
| 18. | A Two-Step Continuous Flow Synthesis of N-(2-Aminoethyl)acylamides via Ring- Opening/Hydrogenation of Oxazolines B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe, Chem. Eur. J. 2011, 17, 13146–13150. DOI: 10.1002/chem.201102772 (featured in Synfacts 2012, 8, 221). |
| 17. | Unusual Behavior in the Reactivity of 5-Substituted-1H-tetrazoles in a Resistance-Heated Microreactor B. Gutmann, T. N. Glasnov, T. Razzaq, W. Goessler, D. M. Roberge, C. O. Kappe, Beilstein. J. Org. Chem. 2011, 7, 503-517. DOI: 10.3762/bjoc.7.59 |
| 16. | Pentafluorophenyl-bis(diethylamino)phosphane – A Push-Pull Phosphane Available for Coordination A. Orthaber, M. Fuchs, F. Belaj, G. N. Rechberger, C. O. Kappe, R. Pietschnig, Eur. J. Inorg. Chem. 2011, 2588-2596. DOI: 10.1002/ejic.201100138 |
| 15. | Continuous Flow Ozonolysis in a Laboratory Scale Reactor M. Irfan, T. N. Glasnov, C. O. Kappe, Org. Lett. 2011, 14, 984-987. DOI: 10.1021/ol102984h |
| 14. | Toward a Continuous Flow Synthesis of Boscalid T. N. Glasnov, C. O. Kappe, Adv. Synth. Catal. 2010, 352, 3089-3097. DOI: 10.1002/adsc.201000646 |
| 13. | Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles and Hydrazoic Acid Using a Safe and Scalable High-Temperature Microreactor Approach B. Gutmann, J.-P. Roduit, D. Roberge, C. O. Kappe, Angew. Chem. Int. Ed. 2010, 49, 7101-7105. DOI: 10.1002/anie.201003733 |
| 12. | Diversity-Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave-Assisted Intramolecular A3-Coupling Reaction J. B. Bariwal, D. S. Ermolat’ev, T. N. Glasnov, K. Van Hecke, V. P. Mehta, L. Van Meervelt, C. O. Kappe, E. Van der Eycken, Org. Lett. 2010, 13, 2774–2777. DOI: 10.1021/ol1008729 |
| 11. | Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes M. Damm, T. N. Glasnov, C. O. Kappe, Org. Process Res. Dev. 2010, 14, 215-224. DOI: 10.1021/op900297e |
| 10. | Mechanistic Insights Into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions Using Continuous Flow Conditions M. Fuchs, W. Goessler, C. Pilger, C. O. Kappe, Adv. Synth. Catal. 2010, 352, 323-328. DOI: 10.1002/adsc.200900726 |
| 9. | Accessing Novel Process Windows in a High-Temperature/Pressure Capillary Flow Reactor T. Razzaq, T. N. Glasnov, C. O. Kappe, Chem. Eng. Technol. 2009, 32, 1702-1716. DOI: 10.1002/ceat.200900272 |
| 8. | Continuous Flow Microreactor Chemistry Under High Temperature/Pressure Conditions T. Razzaq, T. N. Glasnov, C. O. Kappe, Eur. J. Org. Chem. 2009, 1321-1325. DOI: 10.1002/ejoc.200900077 |
| 7. | Continuous Flow Hydrogenation of Functionalized Pyridines M. Irfan, E. Petricci, T. N. Glasnov, M. Taddei, C. O. Kappe, Eur. J. Org. Chem. 2009, 1326-1334. DOI: 10.1002/ejoc.200801131 |
| 6. | Heterogeneous Versus Homogeneous Palladium Catalysts for Ligandless Mizoroki-Heck Reactions. A Comparison of Batch/Microwave and Continuous Flow Processing T. N. Glasnov, S. Findenig, C. O. Kappe, Chem. Eur. J. 2009, 15, 1001-1015. DOI: 10.1002/chem.200802200 |
| 5. | Palladium(0) Nanoparticles on Glass-Polymer Composite Materials as Recyclable Catalysts: A Comparison Study on Their Use in Batch and Continuous Flow Processes K. Mennecke, R. Cecilia, T. N. Glasnov, S. Gruhl, C. Vogt, A. Feldhoff, M. A. L. Vargas, C. O. Kappe, U. Kunz, A. Kirschning, Adv. Synth. Catal. 2008, 350, 717-730. DOI: 10.1002/adsc.200700510 |
| 4. | Microwave-assisted Dimroth Rearrangement of Thiazines to Dihydropyrimidinethiones: Synthetic and Mechanistic Aspects. T. N. Glasnov, D. J. Vugts, M. M. Koningstein, B. Desai, W. M. F. Fabian, R. V. A. Orru, C. O. Kappe, QSAR Comb. Sci. 2006, 25, 509-518. DOI: 10.1002/qsar.200540210 |
| 3. | Microwave-assisted Solution Phase Synthesis of Dihydropyrimidine C5 Amides and Esters B. Desai, D. Dallinger, C. O. Kappe, Tetrahedron 2006, 62, 4651-4664. DOI: 10.1016/j.tet.2005.12.061 |
| 2. | Monolithic Polymer/Carrier Materials: Versatile Composites for Fine Chemical Synthesis U. Kunz, A. Kirschning, H.-L. Wen, W. Solodenko, R. Cecilia, C. O. Kappe, T. Turek, Catal. Today 2005, 105, 318-324. DOI: 10.1016/j.cattod.2005.06.046 |
| 1. | Heterogeneous Hydrogenation Reactions Using a Continuous Flow High Pressure Device B. Desai, C. O. Kappe, J. Comb. Chem. 2005, 7, 641-643. DOI: 10.1021/cc050076x |