Flow Chemistry – Review Articles
A complete list of publications of C. O. Kappe can be found at his Web of Science account
| 34. | Mechanochemistry: From Classical Grinding to Modern and Scalable Process Technologies I. S. Manisha, S. B. Ötvös, N. M. Sekhar, C. O. Kappe, R. Bandichhor, A. Mondal, Chem. Eur. J. 2026, 32, in press. DOI: 10.1002/chem.71608 |
| 33. | Sustainable and Scalable Transformations in Aqueous Media Enabled by Continuous Processing S. B. Ötvös, C. O. Kappe, Curr. Opin. Green Sust. Chem. 2026, 60, 101081. DOI: 10.1016/j.cogsc.2026.101081 |
| 32. | Scaling Mechanochemistry via Continuous Bead Milling Technology S. B. Ötvös, C. O. Kappe, Chim. Oggi/Chem. Today 2026, 44(2), 8-12. |
| 31. | Automating Synthetic Organic Electrochemistry: Concepts and Advancements E. Rial-Rodríguez, C. O. Kappe, G. Laudadio, Chem. Methods 2025, 5, e202500104. DOI: 10.1002/cmtd.202500104 |
| 30. | Dynamic Flow Experiments for Data-Rich Optimization J. D. Williams, P. Sagmeister, C. O. Kappe, Curr. Opin. Green Sust. Chem. 2024, 47, 100921. DOI: 10.1016/j.cogsc.2024.100921 |
| 29. | The Rocky Road to a Digital Lab P. Sagmeister, J. D. Williams, C. O. Kappe, CHIMIA 2023, 77, 300-306. DOI: 10.2533/chimia.2023.300 |
| 28. | Catalytic Static Mixers for Flexible and Scalable Hydrogenation Reactions in Continuous Flow J. D. Williams, C. O. Kappe, Chim. Oggi/Chem. Today 2022, 40(4), 6-9. |
| 27. | Towards the Standardization of Flow Chemistry Protocols for Organic Reactions C. A. Hone, C. O. Kappe, Chem. Methods 2021, 1, 454–467. DOI: 10.1002/cmtd.202100059 |
| 26. | Continuous Flow Asymmetric Synthesis of Chiral Active Pharmaceutical Ingredients and their Advanced Intermediates S. Ötvös, C. O. Kappe, Green Chem. 2021, 23, 6117–6138. DOI: 10.1039/D1GC01615F |
| 25. | Oscillatory Flow Reactors for Synthetic Chemistry Applications P. Bianchi, J. D. Williams, C. O. Kappe, J. Flow. Chem. 2020, 10, 475-490. DOI: 10.1007/s41981-020-00105-6 |
| 24. | The Concept of ”Chemical Generators”: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow D. Dallinger, B. Gutmann, C. O. Kappe, Acc. Chem. Res. 2020, 53, 1330-1341. DOI: 10.1021/acs.accounts.0c00199 |
| 23. | Membrane Microreactors for the On‐Demand Generation, Separation and Reaction of Gases C. A. Hone, C. O. Kappe, Chem. Eur. J. 2020, 26, 13108–13117. DOI: 10.1002/chem.202001942 |
| 22. | Recent Advances towards Sustainable Flow Photochemistry J. D. Williams, C. O. Kappe, Curr. Opin. Green Sust. Chem. 2020, 10, 100351. DOI: 10.1016/j.cogsc.2020.05.001 |
| 21. | Modern Flow Photochemistry: Case Studies in Reaction Development toward Industrial Scale Processing J. D. Williams, C. O. Kappe, Chim. Oggi/Chem. Today 2019, 37(5), 36-39. |
| 20. | The Use of Molecular Oxygen for Liquid Phase Aerobic Oxidations in Continuous Flow C. A. Hone, C. O. Kappe, Top. Curr. Chem. 2019, 377, 2. DOI: 10.1007/s41061-018-0226-z |
| 19. | My Twenty Years in Microwave Chemistry: From Kitchen Ovens to Microwaves that aren’t Microwaves C. O. Kappe, Chem. Rec. 2019, 19, 15-39. DOI: 10.1002/tcr.201800045 |
| 18. | Forbidden Chemistries – Paths to a Sustainable Future Engaging Continuous Processing B. Gutmann, C. O. Kappe, J. Flow. Chem. 2017, 7, 65-71. DOI: 10.1556/1846.2017.00009 |
| 17. | Why Flow Means Green – Evaluating the Merits of Continuous Processing in the Context of Sustainability D. Dallinger, C. O. Kappe, Curr. Opin. Green Sust. Chem. 2017, 7, 6-12. DOI: 10.1016/j.cogsc.2017.06.003 |
| 16. | Halogenation of Organic Compounds using Continuous Flow and Microreactor Technology D. Cantillo, C. O. Kappe, React. Chem. Eng. 2017, 2, 7-19. DOI: 10.1039/C6RE00186F |
| 15. | The Use of Molecular Oxygen in Pharmaceutical Manufacturing – Is Flow the Way to Go? C. A. Hone, D. Roberge, C. O. Kappe, ChemSusChem 2017, 10, 32-41. DOI: 10.1002/cssc.201601321 |
| 14. | Enabling Technologies for Diazomethane Generation and Transformation D. Dallinger, C. O. Kappe, Aldrichim. Acta 2016, 49, 57-66. |
| 13. | Aerobic Oxidations in Continuous Flow B. Pieber, C. O. Kappe, Top. Organometal. Chem. 2016, 57, 97-137. DOI: 10.1007/3418_2015_133 |
| 12. | Taming „Forbidden“ Olefin Reductions Using Hydrazine and Oxygen by Continuous Flow Technology B. Pieber, C. O. Kappe, Chim. Oggi/Chem. Today 2016, 34(3), 38-42. |
| 11. | Continuous-Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients B. Gutmann, D. Cantillo, C. O. Kappe, Angew. Chem. Int. Ed. 2015, 54, 6688-6729. DOI: 10.1002/anie.201409318 (Web of Science “Highly Cited Paper”). |
| 10. | Homogeneous Vs Immobilized Palladium Catalysts for Continuous Flow Cross-Coupling Chemistry D. Cantillo, C. O. Kappe, Chim. Oggi/Chem. Today 2015, 33(S), 6-10. |
| 9. | Forbidden Chemistries Go Flow in API Synthesis B. Gutmann, C. O. Kappe, Chim. Oggi/Chem. Today 2015, 33(3), 14-18. |
| 8. | Immobilized Transition Metals as Catalysts for Cross-Couplings in Continuous Flow – A Critical Assessment of the Reaction Mechanism and Metal Leaching D. Cantillo, C. O. Kappe, ChemCatChem 2014, 6, 3286-3305. DOI: 10.1002/cctc.201402483 |
| 7. | Anthropogenic Reaction Parameters – The Missing Link between Chemical Intuition and the Available Chemical Space M. Keserű, T. Soós, C.O. Kappe, Chem. Sov. Rev. 2014, 43, 5387-5399. DOI: 10.1039/c3cs60423c |
| 6. | The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous Flow Processes T. N. Glasnov, C. O. Kappe, Chem. Eur. J. 2011, 17, 11956-11968. DOI: 10.1002/chem.201102065 |
| 5. | Heterogeneous Catalytic Hydrogenation Reactions Using Continuous Flow Reactors M. Irfan, T. N. Glasnov, C. O. Kappe, ChemSusChem, 2011, 4, 300-316. DOI: 10.1002/cssc.201000354 |
| 4. | Continuous Flow Synthesis of Heterocycles T. N. Glasnov, C. O. Kappe, J. Heterocycl. Chem. 2011, 48, 11-29. DOI: 10.1002/jhet.568 |
| 3. | Continuous Flow Organic Synthesis under High Temperature/Pressure Conditions T. Razzaq, C.O. Kappe, Chem. Asian J. 2010, 5, 1274-1289. DOI: 10.1002/asia.201000010 (Web of Science “Highly Cited Paper”). |
| 2. | Click Chemistry under Non-classical Reaction Conditions C.O. Kappe, E. Van der Eycken, Chem. Soc. Rev. 2010, 39, 1280-1290. DOI: 10.1039/b901973c (Web of Science “Highly Cited Paper”). |
| 1. | Microwave-Assisted Synthesis under Continuous Flow Conditions T. N. Glasnov, C.O. Kappe, Macromol. Rapid Commun. 2007, 28, 395-410. DOI: 10.1002/marc.200600665 |